Color Doppler imaging of cervicocephalic fibromuscular dysplasia
© Arning and Grzyska; licensee BioMed Central Ltd. 2004
Received: 08 July 2004
Accepted: 20 July 2004
Published: 20 July 2004
Fibromuscular dysplasia (FMD) is a possible cause of stroke, especially in middle-aged women. However, only few reports are available on ultrasonographic detection and monitoring.
Among the 15,000 patients who underwent color Doppler imaging (CDI) of the cervicocephalic arteries during the study period, all cases fulfilling ultrasound criteria of FMD were included into the case series. Criteria of FMD were: 1. Segmental string-of-beads pattern, 2. Localization in the distal extracranial part of internal carotid artery (ICA) or vertebral artery (VA), and 3. (optional): Direct and/or indirect criteria of stenosis.
CDI detected FMD in 39 vessels (37 ICA and 2 VA segments) of 21 patients. 16 patients had bilateral manifestation on ICA, one of those also on VA, bilaterally. CDI disclosed 4 symptomatic high-grade ICA stenoses, 3 of them underwent endovascular treatment. 5 patients with moderate symptomatic ICA stenoses got medical treatment. In 6 patients FMD was the most likely cause of headache and in one patient FMD was diagnosed as a cause of vertigo.
CDI may be used for detection of cervicocephalic FMD. Due to the unfavourable localisation of FMD for CDI, the sensitivity of CDI is lower in comparison to angiography. However, high-grade FMD stenoses that require invasive treatment can be recognized on the basis of indirect hemodynamic criteria.
Fibromuscular dysplasia (FMD) is a non-atheromatous, non-inflammatory arteriopathy of unknown etiology with segmental manifestation on medium-sized arteries in various regions of the body . Manifestation on the renal arteries with the possible consequence of renovascular hypertension is remarkably frequent . The cervico-cephalic arteries, especially the internal carotid artery (ICA) are attacked with an incidence of about 0.6 – 1%, often bilaterally ; manifestation also occurs on the vertebral artery (VA) . The disease can occur at any age but is usually diagnosed in middle-aged, predominately female individuals .
Clinical manifestations of FMD on the ICA are transitoric ischemic attacks or cerebral infarctions  as well as unspecific symptoms such as headache and vertigo. In cases of cerebrovascular events, endovascular or surgical treatment is recommended [7–9], therefore detection of FMD is of considerable importance.
Patients and methods
Color Doppler ultrasound criteria of FMD
1. Morphological criteria:
Segmental string-of-beads pattern with alternating regions of lumen narrowing and vessel dilatation
Distal extracranial part of ICA (VA).
3. Hemodynamics (optional):
Direct and/or indirect criteria of stenosis (in distal extracranial part of ICA / VA).
Patients and symptoms
Transient ischemic attack
Amaurosis fugax, vertigo
Bruit, headache, vertigo
Transient ischemic attack
Transient ischemic attack
The color Doppler examinations were performed as described by Arning  and included the common carotid, external carotid, and internal carotid arteries as well as the vertebral arteries.
CDI was performed with 5 MHz and 7 MHz linear array transducers using one of the following systems: Acuson Sequoia (Siemens AG, Erlangen, Germany), Toshiba Powervision 6000 or Toshiba Aplio (Toshiba Medical Systems Europe, Zoetermeer, Netherlands), or ATL HDI 5000 (Philips Medical Systems, Andover, MA).
Using the criteria of table 1, FMD was diagnosed in 21 patients (1 male, 20 female). In total, CDI detected FMD in 39 vessels (37 ICA and 2 VA segments). 16 patients had bilateral manifestation on ICA, one of those also on VA, bilaterally. 5 patients had unilateral manifestation on ICA.
FMD is an uncommon angiopathy with an incidence on the ICA of about 0.6 – 1% . However, the frequency of FMD detection by ultrasound imaging is considerably lower: 0,14% in our case series. Only few reports are available on the detection and monitoring of cervicocephal FMD with ultrasonography [11–14].
Ultrasound criteria of FMD correspond to those of angiography (Fig. 1). CDI reveals the segmental string-of-beads pattern with alternating regions of lumen narrowing and vessel dilatation (Fig. 2,3), distally to a completely normal segment of the vessel (Fig. 6). Dependent on the degree of stenosis, direct (Fig. 8) or indirect hemodynamic criteria may be recognized .
In comparison to angiography, the sensitivity of CDI is low: The vascular lesion can only be visualized sonographically when it is located not too far cranially on the ICA . However, high-grade FMD stenoses will be detected on the basis of indirect hemodynamic criteria. To overlook asymptomatic cases of low grade or medium grade stenosing lesions will not have a negative consequence since they do not require any treatment .
CDI allows diagnosis of FMD in numerous cases. Due to the unfavourable localisation of FMD for CDI, the sensitivity of CDI is low in comparison to angiography. However, high-grade FMD stenoses that require invasive treatment can be recognized on the basis of indirect hemodynamic criteria.
List of abbreviations
Color Doppler Imaging
Internal Carotid Artery
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