Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report

Table 1 Testing of pulmonary vasoreactivity at initial investigation and after six months of PDE-5 inhibitor therapy with right heart catheter

	HR	RR mmHg syst/diast (mean)	PAP mmHg syst/diast (mean)	RA mmHg	PCWP mmHg	CI l/min/m ²	SV ml/m ²	TPR dyn × sec × cm ^-5	PVR dyn × sec × cm ^-5
baseline	103	140/89 (104)	87/37 (56)	28	8	1,9	33	3.178	1.128
baseline sildenafil	96	106/58 (76)	74/14 (26)	13	3	2,2	41	1.290	760
six months sildenafil	96	105/71 (88)	64/27 (43)	8	4	2,6	46	1.453	708
six months vardenafil	102	114/69 (83)	63/25 (40)	6	6	2,6	44	1.403	604

baseline = initial investigation; baseline sildenafil = 90 minutes after first dose of 25 mg sildenafil p.o.; six months sildenafil = after 6 months of therapy with sildenafil; six months vardenafil = 120 minutes after first dose of 10 mg vardenafil p.o. HR = heart rate; RR = blood pressure; PAP = pulmonary arterial pressure; RA = right atrial pressure; PCWP = pulmonary capillary wedge pressure; CI = cardiac index; SV = stroke volume; TPR = total peripheral resistance; PVR = pulmonary vascular resistance.

ISSN: 1476-7120