Echocardiographic assessment of diastolic dysfunction in elderly patients with severe aortic stenosis before and after aortic valve replacement

Table 3 ROC curve analysis of echocardiographic parameters to predict NT-proBNP ≥500 ng/L in patients with severe aortic stenosis

N = 210 NT-proBNP ≥500 N = 123 NT-proBNP < 500	AUC	CI Lower bound	CI Upper bound	P-value
e’septal (cm/s)	0.68	0.62	0.73	< 0.0001
e’lateral (cm/s)	0.62	0.55	0.68	0.001
e’avrg (cm/s)	0.62	0.56	0.68	0.002
E/e’sept ()	0.70	0.65	0.76	< 0.0001
E/e’lat ()	0.63	0.56	0.69	< 0.0001
E/e’avrg ()	0.67	0.61	0.73	< 0.0001
PV SFF	0.68	0.63	0.74	< 0.0001
LA volume (ml)	0.73	0.67	0.79	< 0.0001
MV peak E (cm/s)	0.64	0.58	0.70	0.050
MV peak A (cm/s)	0.50	0.44	0.57	0.939
MV E/A ()	0.57	0.51	0.64	0.037
MV dec time (ms)	0.66	0.61	0.72	< 0.0001
IVRT (ms)	0.56	0.50	0.62	0.057
PAP (mmHg)	0.68	0.63	0.74	< 0.0001
Score 2016	0.72	0.67	0.78	< 0.0001
Score 1 e’sept	0.76	0.71	0.82	< 0.0001
Score 2 E/é avrg	0.70	0.65	0.77	< 0.0001

A Late (atrial) diastolic transmitral flow velocity, AUC Area Under the Curve, CI Confidence interval, E Early diastolic transmitral flow velocity, e′ Early diastolic mitral annuler velocity, IVRT Isovolumic relaxation time, LA Left atrium, MV dec time Mirtal valve deceleration time, MV peak E Mitral valve early diastolic filling velocity, MV peak A Mitral valve late diastolic atrial filling velocity, NT-proBNP N-terminal prohormone of brain natriuretic peptide, PAP Pulmonary artery pressure, ROC Receiver operating characteristic

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