Cross-section of a coronary artery containing a thin-cap fibroatheroma (TCFA). Images from microscopy are shown at the top, images obtained with an intracoronary imaging technology at the bottom (necrotic core displayed in yellow (asterisk), fibrous tissue in blue). The observer can imagine herself/himself looking at the cross-sectional image standing either proximal or distal to the cross-section. From these two opposite imagined points of view the observer sees mirror images, i.e. the images have different spatial orientations and are not superimposable. Although a TCFA is seen from both points of view, only images viewed from the same point of view have similar intraplaque localization of plaque components. Comparing intraplaque location on images only makes sense if seen from the same point of view. Microscopy: trichrome stain (collagen blue, necrotic core colorless).