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Table 3 Single parameters selected as significant predictors of coronary stenosis in separate myocardial segments

From: Quantitative approach using multiple single parameters versus visual assessment in dobutamine stress echocardiography

Method Parameter Cut-off AUC (95 % CI) Sensitivity % (95 % CI) Specificity % (95 % CI) Accuracy % (95 % CI) Youden index
Basal inferoseptal segment
PW-DMI T to S' stress 70.5 0.66* (0.54;0.78) 56.7 (37.4;74.5) 76.7 (68.1;83.9) 72.7 (64.8;79.6) 0.33
  S' stress - S' rest 4.15 0.65* (0.53;0.76) 56.7 (37.4;74.5) 73.1 (64.2;80.8) 69.8 (61.7;77.0) 0.30
  A' stress 12.3 0.64* (0.53;0.75) 46.7 (28.3;65.7) 81.4 (73.0;88.1) 74.1 (66.1;81.1) 0.28
CC-DMI E'/A' rest 0.64 0.66* (0.55;0.76) 64.3 (44.1;81.4) 68.2 (58.6;76.7) 67.4 (58.9;75.1) 0.33
STI E' stress 4.5 0.70* (0.58;0.83) 66.7 (44.7;84.4) 71.6 (61.0;80.7) 70.5 (61.2;78.8) 0.38
  E'/A' stress 0.34 0.66* (0.52;0.80) 47.6 (25.7;70.2) 88.1 (79.2;94.1) 80.0 (71.1;87.2) 0.36
Mid inferoseptal segment
CC-DMI PSI stress /SS stress 0.13 0.65* (0.54;0.77) 58.1 (39.1;75.5) 69.1 (59.6;77.6) 66.7 (58.2;74.4) 0.27
  SSR stress - SSR rest −0.21 0.64* (0.53;0.74) 74.2 (55.4;88.1) 55.9 (46.1;65.3) 59.9 (51.3;68.0) 0.30
Apical inferoseptal segment
STI PSI rest /SS rest −0.15 0.65*(0.54;0.76) 70.0 (50.6;85.3) 57.9 (48.3;67.1) 60.4 (51.9;68.5) 0.28
  PSI rest 3.85 0.65*(0.54;0.76) 70.0 (50.6;85.3) 56.1 (46.5;65.4) 59.0 (50.5;67.1) 0.26
  RSSR rest 1.95 0.63*(0.53;0.74) 90.0 (73.5;97.9) 34.2 (25.6;43.7) 45.8 (37.5;54.3) 0.24
Basal inferior segment
PW-DMI S' stress 10.8 0.65* (0.53;0.76) 48.3 (29.4;67.5) 77.3 (68.7;84.5) 71.6 (63.6;78.7) 0.26
  S' stress - S' rest 4.8 0.64* (0.53;0.75) 75.9 (56.5;89.7) 52.1 (42.8;61.3) 56.8 (48.4;64.9) 0.28
  T to S' stress - T to S' rest −45.5 0.64* (0.53;0.75) 62.1 (42.3;79.3) 65.5 (56.3;74.0) 64.9 (56.6;72.5) 0.28
  (T to S' stress - T to S' rest )/T to S' rest −0.44 0.66* (0.55;0.76) 69.0 (49.2;84.7) 58.0 (48.6;67.0) 60.1 (51.8;68.1) 0.27
  E' rest 9.35 0.64* (0.54;0.74) 93.3 (77.9;99.2) 34.2 (25.8;43.4) 46.0 (37.8;54.3) 0.28
  E' stress 7.53 0.72* (0.62;0.82) 72.4 (52.8;87.3) 66.1 (56.7;74.7) 67.4 (59.1;74.9) 0.39
CC-DMI PSI stress /PSS stress 0.06 0.65* (0.52;0.78) 66.7 (44.7;84.4) 61.9 (51.4;71.5) 62.8 (53.6;71.4) 0.29
STI SS rest −13.0 0.65* (0.54;0.77) 41.4 (23.5;61.1) 88.7 (81.4;93.8) 79.2 (71.6;85.5) 0.30
Mid inferior segment
PW-DMI T to S' stress - T to S' rest −41.9 0.64* (0.53;0.75) 66.7 (47.2;82.7) 64.1 (54.7;72.8) 64.6 (56.3;72.3) 0.31
CC-DMI SS stress −14.5 0.66* (0.56;0.76) 75.0 (55.1;89.3) 55.8 (46.1;65.1) 59.6 (51.0;67.7) 0.31
STI PSSR rest −0.65 0.64* (0.52;0.76) 41.4 (23.5;61.1) 87.0 (79.4;92.5) 77.8 (70.1;84.3) 0.28
  (PSI stress - PSI rest )/PSI rest −0.08 0.67* (0.56;0.78) 48.3 (29.4;67.5) 81.3 (72.8;88.0) 74.5 (66.4;81.4) 0.30
Basal anterior segment
PW-DMI S' stress 8.2 0.63* (0.52;0.74) 75.8 (57.7;88.9) 44.2 (34.9;53.9) 51.4 (43.0;59.7) 0.20
CC-DMI S' stress 6.2 0.69* (0.59;0.79) 51.7 (32.5;70.6) 81.3 (72.8;88.0) 75.2 (67.2;82.1) 0.33
  (PS' stress - PS' rest )/PS' rest 3.1 0.69* (0.54;0.84) 53.3 (26.6;78.7) 83.1 (71.0;91.6) 77.0 (65.8;86.0) 0.36
  SSR stress −2.4 0.65* (0.54;0.75) 80.0 (61.4;92.3) 52.7 (43.0;62.2) 58.5 (49.9;66.7) 0.33
STI PSI stress - PSI rest −5.5 0.64* (0.53;0.75) 40.0 (22.7;59.4) 87.3 (79.6;92.9) 77.1 (69.3;83.8) 0.27
  PSSR rest −1.1 0.68* (0.58;0.78) 80.0 (61.4;92.3) 47.4 (37.9;56.9) 54.2 (45.7;62.5) 0.27
  PSSR stress - PSSR rest −0.39 0.67* (0.56;0.78) 80.0 (61.4;92.3) 56.8 (47.0;66.1) 61.7 (53.1;69.8) 0.37
Basal inferolateral segment
PW-DMI S' stress 12.1 0.65* (0.54;0.76) 70.4 (49.8;86.2) 57.3 (47.8;66.4) 59.7 (51.2;67.8) 0.28
  E' stress 8.1 0.66* (0.53;0.78) 64.0 (42.5;82.0) 68.7 (59.4;77.0) 67.9 (59.4;75.5) 0.33
  E'/A' stress 0.51 0.69* (0.57;0.80) 56.0 (34.9;75.6) 76.3 (67.4;83.8) 72.7 (64.5;79.9) 0.32
Mid inferolateral segment
CC-DMI E'/A' rest 0.5 0.65* (0.54;0.76) 61.5 (40.6;79.8) 70.9 (61.5;79.2) 69.1 (60.6;76.8) 0.32
  SS stress −16.0 0.72* (0.62;0.82) 80.8 (60.6;93.4) 59.8 (50.1;69.0) 63.8 (55.2;71.8) 0.41
  SSR stress −1.4 0.68* (0.56;0.80) 64.0 (42.5;82.0) 71.2 (61.8;79.4) 69.9 (61.4;77.4) 0.35
Mid anteroseptal segment
PW-DMI PS' stress - PS' rest 1.8 0.66* (0.55;0.76) 86.2 (68.3;96.1) 52.3 (42.5;62.1) 59.6 (50.8;67.9) 0.39
  (PS' stress - PS' rest )/PS' rest 0.86 0.70* (0.58;0.82) 81.8 (59.7;94.8) 70.2 (59.3;79.7) 72.6 (63.1;80.9) 0.52
CC-DMI E' stress 3.5 0.72* (0.61;0.83) 84.6 (65.1;95.6) 51.2 (39.9;62.4) 59.3 (49.4;68.6) 0.36
STI PSI stress /SS stress 0.14 0.64* (0.54;0.75) 67.9 (47.6;84.1) 59.0 (49.0;68.5) 60.9 (52.1;69.2) 0.27
  1. P ≤ 0.025 for AUC > 0.5, * P < 0.05 compared with AUC of visual assessment 0.88; PW-DMI = pulsed wave Doppler myocardial imaging; CC-DMI = color coded Doppler myocardial imaging; STI = speckle tracking imaging; AUC = area under the curve; CI = confidence interval; S' = peak systolic velocity; PS' = peak post-systoloc velocity; E' = early diastolic wave; A' = late diastolic wave; SS = peak systolic strain, PSS = peak post-systolic strain; PSI = post-systolic index; SSR = systolic strain rate; PSSR = post-systolic strain rate; T = time; RSSR = radial systolic strain rate; RPSSR = radial post-systolic strain rate.