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Table 1 DXR group data at basal and at DXR cumulative dosages of 8, 10, 12, 14 and 16 mg/Kg expressed in average and standard error values

From: Early detection of doxorubicin myocardial injury by ultrasonic tissue characterization in an experimental animal model

DOXORUBICIN
DOSE 0 8 10 12 14 16
N 60 23 21 14 9 7
MCV 11.0 ±2.6 9.1 ±2.8 8.4 ±2.3 8.2± 2 7.2 ±1.5 8.8 ±0.6
CC IBS 1.1 ±0.3 1.3± 0.27 1.2 ±0.1 1.4± 0.2 1.3 ±0.2 1.4 ±0.1
LVEF (%) 85.3± 6.9 80.4± 6.9 81.3± 5.6 76.4± 6.6 75.6± 4.8 67.3± 10
SF (%) 50±7.3 45.2 ±6.9 45.3 ±5.4 40.8 ±6.4 39.9 ±4.2 33.4± 7
Col (%) 1.7 ± 0.6 5.6± 1.6   10.6 ±2.5   9.6± 0.7
  (N=6)* (N=8) *   (N=6)*   (N=10)*
  1. N=animal number; MCV= magnitude of cyclic variation of IBS; CC IBS= corrected coefficient of IBS; EF Teic= Left ventricle ejection fraction (Teichholz); SF=left ventricle shortening fraction; Col=collagen percentage.* number of animals submitted to collagen analysis.