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Table 1 DXR group data at basal and at DXR cumulative dosages of 8, 10, 12, 14 and 16 mg/Kg expressed in average and standard error values

From: Early detection of doxorubicin myocardial injury by ultrasonic tissue characterization in an experimental animal model

DOXORUBICIN

DOSE

0

8

10

12

14

16

N

60

23

21

14

9

7

MCV

11.0 ±2.6

9.1 ±2.8

8.4 ±2.3

8.2± 2

7.2 ±1.5

8.8 ±0.6

CC IBS

1.1 ±0.3

1.3± 0.27

1.2 ±0.1

1.4± 0.2

1.3 ±0.2

1.4 ±0.1

LVEF (%)

85.3± 6.9

80.4± 6.9

81.3± 5.6

76.4± 6.6

75.6± 4.8

67.3± 10

SF (%)

50±7.3

45.2 ±6.9

45.3 ±5.4

40.8 ±6.4

39.9 ±4.2

33.4± 7

Col (%)

1.7 ± 0.6

5.6± 1.6

 

10.6 ±2.5

 

9.6± 0.7

 

(N=6)*

(N=8) *

 

(N=6)*

 

(N=10)*

  1. N=animal number; MCV= magnitude of cyclic variation of IBS; CC IBS= corrected coefficient of IBS; EF Teic= Left ventricle ejection fraction (Teichholz); SF=left ventricle shortening fraction; Col=collagen percentage.* number of animals submitted to collagen analysis.
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Cardiovascular Ultrasound

ISSN: 1476-7120

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