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Table 2 Study characteristics

From: Tissue Doppler imaging for diagnosis of coronary artery disease: a systematic review and meta-analysis

Author, Year (Reference) Study design CAD (N) No CAD (N) Segments studied Type of tissue doppler Machine used
Bolognesi, 2001[12] Prospective controlled study Stable effort angina without previous MI and with normal EF, CAD confirmed with angiography(16) Negative noninvasive coronary stress tests and normal electrocardiographic and echocardiographic findings in volunteers undergoing cardiac catheterization (6) Apical four chamber view: septal and anterolateral Not reported Toshiba 380, Rome, Italy
Apical two chamber view: anterior and inferior
Bruch, 1999[13] Prospective controlled study CAD on angiogram (>70% LAD), no previous MI or cardiac surgery and no echo evidence of regional or global wall motion abnormalities (17) Normal resting electrocardiogram and a normal regional and global systolic left ventricular function on echocardiogram (20) Apical four chamber view: midseptal and midlateral Color-coded pulsed-wave Toshiba 380, Rome, Italy
Dounis, 2006[14] Prospective controlled study 1-2 vessel disease, confirmed by angiogram, normal EF and sinus rhythm (17) No CAD confirmed by either angiogram or stress testing, normal EF and sinus rhythm(14) Apical four-, two- and three-chamber views: septal, anteroseptal, anterior, lateral, posterior and inferior Spectral pulsed-wave System V, GE Milwaukee, USA
Hoffmann, 2010[15] Prospective controlled study Significant one, two or three vessel disease included. (47) Suspected angina pectoris and non significant stenosis on angiogram. (35) Septal, lateral, inferior, anterior, posterior, and anteroseptal Color-coded pulsed-wave Vivid 7, GE Healthcare, Horton, Norway
Madler, 2003[16] Prospective controlled study Significant stenosis (>50%) on coronary angiography (90) Chest pain with no significant stenosis (<50%)on coronary angiography (59) Apical four and two chamber view: basal septal, basal anterior, basal lateral and basal inferior and mid septal, mid anterior, mid lateral and mid inferior Color-coded pulsed-wave System V, GE Vingmed, Horten, Norway
Tsougos, 2008[17] Prospective controlled study Stenosis >70% of at least one coronary artery (72) No significant stenosis on angiography (42) Apical four-chamber view: septal and lateral Spectral pulsed-wave Vivid 3, GE Vingmed Horten, Norway
Williams, 2005[18] Prospective controlled study Angiography confirmed >50% stenosis in at least one major coronary artery branch; chronic stable symptoms and normal resting global/regional LV function assessed by left ventriculography and echocardiography (16) Normal coronary angiography; negative, maximum, Bruce protocol exercise testing, and low probability of coronary artery disease (12) American Society of Echocardiography 16 segment model Color-coded pulsed-wave System V, GE Vingmed, Horten, Norway
Zagatina, 2007[19] Prospective controlled study Significant stenosis in the LAD on angiography (88) Normal angiogram (17) Long and short-axis parasternal views and the four and two-chamber apical views: basal and mid-septum, basal and midlateral, inferior and anterior Spectral pulsed-wave Hewlett Pacard Sonos 2000
  1. Abbreviations: CAD coronary artery disease, EF ejection fraction, LAD left anterior descending, LV left ventricle, MI myocardial infarction.