Figure 1
From: Gene therapy for cardiovascular disease mediated by ultrasound and microbubbles
Schematic diagram of gene therapy mediated by UTMD. Microbubbles carrying therapeutic gene are destroyed at the site of the target tissue, resulting in sonoporation and delivery of the drug directly to the target cell. The process of sonoporation induced by US application leads to transiently holes in cell membrane and capillary, which facilitates the uptake of therapeutic gene.