Figure 10
From: Gene therapy for cardiovascular disease mediated by ultrasound and microbubbles
Arteries harvested on day 28 stained with Elastica van Gieson (EvG). A: Significantly thickened intima in the arteries is seen with ICAM-1 siRNA without ultrasound irradiation; B: B shows significant suppression of neointimal formation in the artery with ICAM-1 siRNA with microbubble administration and ultrasound irradiation. C: VACM-1 siRNA had an effect statistically comparable to that of ICAM-1 siRNA in the prevention of neointimal formation. D: The scrambled siRNA did not suppress neointimal formation [33].