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Figure 2 | Cardiovascular Ultrasound

Figure 2

From: Gene therapy for cardiovascular disease mediated by ultrasound and microbubbles

Figure 2

Exogenous TB4 reprogrammed epicardium layer cells into WT1-positive adult cardiac progenitor cells and then formed new cardiac muscle cells. A: Negative control for 12 weeks post-UTMD-DsRed;B-F: The panels are high power images (scale bar = 50 mm) from TB4-treated rats killed at 1, 2, 3, 4 and 12 weeks after UTMD. WT1 signal from nucleus of epicardium layer cells at 1–3 weeks after UTMD-TB4 treatment and then migrated into myocardium layer to form new cardiac muscle cells (WT1 signal from nucleus of cTnT-positive cells, arrows) at 4 or 12 weeks after UTMD-TB4 treatment [47].

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