Radial strain curves with different degrees of user controlled spatial and temporal smoothing. (A) Epicardial left ventricular short-axis view used for 2-dimensional strain analysis with Speckle Tracking Echocardiography. The left ventricle is divided into 6 standard segments, labeled AntSept (yellow), Ant (cyan), Lat (green), Post (pink), Inf (blue) and Sept (red). Regional radial and circumferential strain was measured within each segment. The anterior and posterior wall was defined as the AntSept and Post segment, respectively. Global strain was calculated as the average value of the six segmental strain values at each frame throughout the heart cycle. The curves show radial strain at baseline with (B) minimal, (C) factory default and (D) maximal degrees of both spatial and temporal smoothing.