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Table 2 Comparison of the intra-class correlation and mean difference for measurements obtained by edge-detection software and manual caliper measurement

From: Reproducibility of aortic intima-media thickness in infants using edge-detection software and manual caliper measurements

  Measurement method
Edge detection Manual caliper
Inter-operator reliability - same reader using cineloops from different ultrasound operators
n = 30 ICC 0.84 (95% CI 0.67, 0.92) n = 30 ICC 0.87 (95% CI 0.73, 0.94)
mean diff 10 μm (95% LOA −39, 59) mean diff 0.8 μm (95% LOA −50.2, 51.8)
Inter-reader reliability - two readers using same ultrasound images
n = 20 ICC 0.92 (95% CI 0.82, 0.97) n = 290 ICC 0.84 (95% CI 0.80, 0.87)
mean diff 2 μm (95% LOA −45.0, 49.0) mean diff 5 μm (95% LOA −51.8, 61.8)
Intra-reader reliability - same ultrasound images read twice by the same reader
n = 20 ICC 0.90 (95% CI 0.76, 0.96) N/A (all read by both readers)
  mean diff 1.5 μm (95% LOA −45.5, 48.5)