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Table 7 Inter- and intra-observer variability for the different LA quantification methods, dense spontaneous spontaneous echocardiographic contrast and left atrial appendage thrombus

From: Which method of left atrium size quantification is the most accurate to recognize thromboembolic risk in patients with non-valvular atrial fibrillation?

Inter-observer variability A vs B A vs C B vs C
LA AP Diameter (mean ± SD,%) 1.05 ± 0.19 1.04 ± 0.2 1.04 ± 0.18
LA Area 4C (mean ± SD,%) 1.03 ± 0.23 1.04 ± 0.24 1.02 ± 0.21
LA Ellipsoid Volume (mean ± SD,%) 1.12 ± 0.36 1.1 ± 0.36 1.08 ± 0.33
LA 1P Area-Lenght Volume (mean ± SD,%) 1.09 ± 0.44 1.11 ± 0.47 1.06 ± 0.41
LA 2P Area-Lenght Volume (mean ± SD,%) 1.05 ± 0.28 1.07 ± 0.28 1.03 ± 0.27
Dense SEC R = 0.797, p < 0.001 R = 0.849, p < 0.001 R = 0.841, p < 0.001
LAA Thrombus R = 0.857, p < 0.001 R =1, p < 0.001 R = 0.857, p < 0.001
Intra-observer variability A B C
LA AP Diameter (mean ± SD,%) 1 ± 0.08 1 ± 0.08 1 ± 0.07
LA Area 4C (mean ± SD,%) 1.01 ± 0.11 1.01 ± 0.09 1.01 ± 0.1
LA Ellipsoid Volume (mean ± SD,%) 1.01 ± 0.1 01.01 ± 0.1 0.98 ± 0.11
LA 1P Area-Lenght Volume (mean ± SD,%) 1.03 ± 0.24 1.02 ± 0.2 1.03 ± 0.22
LA 2P Area-Lenght Volume (mean ± SD,%) 1.01 ± 0.15 1.01 ± 0.15 1.02 ± 0.14
Dense SEC R =0.901, p < 0.001 R =1, p < 0.001 R = 1, p < 0.001
LAA Thrombus R = 1, p < 0.001 R = 1, p < 0.001 R =1, p < 0.001
  1. Legend: LA – left atrial; LAA – left atrial appendage; SEC – spontaneous echocardiographic contrast; 4C – 4-chamber; 1P – single-plane; 2P – biplane.
  2. A, B and C represent the three different echocardiographers.
  3. For LA measurements are presented the results of Bland-Altman analysis, expressed as mean ± SD of the ratio of the measurements in comparison. For dense spontaneous spontaneous echocardiographic contrast and left atrial appendage thrombus are presented the variability is presented as a correlation.