Table 1 Sample characteristics of the 51 included studies

Ayabakan [15]

2003

REF, V, O

72

3 d - 16 y

4

18

Boettler [45]

2005

U

129

1 d - 16.9 y

1

129

Bonatto [9]

2006

REF

595

1 m - 144 m

(Data presented according to BSA)

Cantinotti [59]

2013

A review containing nomograms

Cui [16]

2008

REF

593

1 d - 18 y

1

593

Daubeney [17]

1999

REF, U

125

1 m - 207 m

(Regression equations and Nomograms)

Eidem [36]

1998

V

152

3 y - 18 y

1

152

Eidem [18]

2004

REF

325

1 d - 18 y

5

55 - 81

Frommelt [19]

2002

REF

141

3 d - 18 y

2

27; 114

Goebel [37]

2006

V

45

5 y – 23 y

1

45

Gutgesell [20]

1991

U

70

1 d – 18 y

(Data presented according to BSA)

Hanseus [46]

1988

U

120

3 d – 15.5 y

(Regression equations and Nomograms)

Harada [21]

2000

REF

48

7 d - 18 y

1

48

Hershenson [60]

2010

U

16

5.8 ± 1.7 y

1

16

Hui [44]

2010

O

103

3 - 18 yrs

4

19 - 29

Ichida [38]

1987

O, V

173

0 d – 15 y

7

8 - 21

Innelli [22]

2009

REF, V

40

10 y - 19 y

1

40

Ishii [8]

2000

REF

150

30 d - 18 y

1

150

Jin [23]

1997

REF

108

7 d - 17 y

5

12 - 29

Kampmann [14]

2000

REF, V

2036

1 d - 18 y

(Data presented according to BSA / weight)

Kapusta [47]

2000

V

160

4 y - 17.9 y

1

160

King [24]

1985

REF

103

1 d – 15 y

(Data presented according to BSA)

Koestenberger [26]

2009

REF

640

1 d - 18 y

22

18 - 47

Koestenberger [25]

2012

REF

860

1 m - 18 y

29

8 - 83

(Graphically according to age and BSA)

Kutty [27]

2013

REF

153

<1 - 20 y

5

21 - 24

(Contour plots as a function of age)

Lange [48]

1983

U

185

Birth - 15 y

(Data presented according to BSA / weight)

Lester [39]

1987

V

202

25 d - 23 y

(Data presented according to BSA)

Matsui [49]

2007

U

22

1.6 - 10.8 y

1

22

McQuillan [43]

2001

O

856

< 20 y

1

856

Moiduddin [13]

2010

O

13

5.7 y ± 1.8 y

1

13

Mori [50]

2004

U

396

Birth - 19 y

3

130 - 135

Norgard [51]

1992

U

15

6 y - 16 y

1

15

Nunez-Gil [28]

2011

REF

405

0 d - 18 yrs

9

15 - 77

(Graphically according to weight, height and BS

Pettersen [29]

2008

REF

782

1 day - 18 y

(Data presented according to BSA)

Rafeiyian [30]

2005

REF

100

1 m - 15 y

4

9 - 46

Roberson [31]

2007

REF

634

1 d - 18 y

(Data presented according to BSA)

Roberson [53]

2007

U

308

1 d - 18 y

6

41 - 77

Sarnani [32]

2009

U

179

0.02 m - 19 y

1

179

Seguela [33]

2012

REF

50

2 m - 18 y

1

50

Shedeed [40]

2010

V

60

5 - 15 y

1

60

Singh [41]

1994

V

78

2 m - 50 y

4

7 - 47

Stines [54]

2011

U

16

5.7 ± 1.7 y

1

16

Suleymanoglu [6]

2007

REF

213

15 d - 15 y

(According to weight and graphically for age)

Van der Hulst [55]

2011

U

123

1 m - 18 y

5

(Not presented in tables)

Vignola [12]

1977

V

17

3 y - 17 y

1

17

Weidemann [56]

2002

U

33

4 - 16 y

1

33

Wessel [57]

1985

U

30

(Children – ages not stated)

(Data presented according to weight)

Yusuoka [34]

1999

REF

99 30(TDI)

7 d - 22 y

(Data presented graphically according to age)

Zhendong [58]

1998

U

88

3 y - 12 y

2

41; 47

Zilberman [35]

2005

REF

748

Birth - 18 y

(Data presented according to BSA)