Diastolic wall strain: a simple marker of abnormal cardiac mechanics

Table 4 Association of cardiac mechanics with diastolic wall strain in HyperGEN

Dependent variable	Model 1*		Model 2^†		Model 3^‡		Model 4^§
Dependent variable	β-coefficient (95% CI)	P-value	β-coefficient (95% CI)	P-value	β-coefficient (95% CI)	P-value	β-coefficient (95% CI)	P-value
GRS,%	0.02 (-0.08, 0.12)	0.71	0.12 (0.003, 0.24)	0.049	0.12 (-0.01, 0.25)	0.06	0.16 (0.00, 0.32)	0.046
GCS,%	0.13 (-0.03, 0.06)	0.58	0.05 (0.003, 0.10)	0.037	0.06 (0.01, 0.11)	0.024	0.07 (0.02, 0.14)	0.020
GLS,%	0.10 (0.07, 0.12)	<0.001	0.07 (0.04, 0.10)	<0.001	0.05 (0.02, 0.08)	<0.001	0.07 (0.03, 0.11)	0.001
e’ velocity, cm/s	0.08 (0.07, 0.11)	<0.001	0.03 (0.01, 0.05)	<0.001	—	—	—	—
E/e’ ratio	-0.03 (-0.06, 0.01)	0.15	0.02 (-0.03, 0.06)	0.48	—	—	—	—

*Adjusted for speckle-tracking analyst, image quality, field center, and family relatedness.
†Adjusted for all covariates in Model 1 plus age, sex, left ventricular mass-index, wall motion score index, and ejection fraction.
‡Includes all covariates from Model 2 with additional adjustment for average tissue e’ velocity.
§Includes all covariates from Model 2 with additional adjustment for average E/e’ ratio.
GRS = Global radial strain; GCS = Global circumferential strain; GLS = Global longitudinal strain; E = Early mitral inflow velocity.

ISSN: 1476-7120