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Table 4 Univariate and multivariate analysis of clinical and echocardiographic determinants of NYHA class improvement

From: Determinants of clinical improvement after surgical replacement or transcatheter aortic valve implantation for isolated aortic stenosis

NYHA improvement Univariate analysis   Multivariate analysis  
  OR(95% CI) p   p
Female gender [n(%)] 0.92 (0.31-2.67) 0.87   
Age (years) 1.09 (1.01-1.17) 0.02   
ΔEF (%) 0.99 (0.94-1.04) 0.62   
ΔLVMI (g/ m 2 ) 0.99 (0.97-1.01) 0.49   
ΔLAVI (ml/ m 2 ) 1.01 (0.99-1.02) 0.38   
ΔLVDVI (ml /m 2 ) 0.98 (0.94-1.02) 0.28   
ΔLVSVI (ml/ m 2 ) 0.99 (0.93-1.05) 0.64   
ΔEAOI (%) 8.81 (0.90-86.10) 0.06 3.87 (1.02-14.70) 0.004
ΔE/ e’ 1.01 (0.94-1.08) 0.85   
Hypertension [ n(%)] 1.70 (0.60-5.15) 0.35   
Diabetes Mellitus [n(%)] 0.48 (0.15-1.48) 0.20   
COPD [n(%)] 2.55 (0.75-8.66) 0.14   
PAD [n(%)] 0.80 (0.22-2.96) 0.74   
NYHA class ≥ III [n(%)] 11.33 (2.93-43.78) <0.001 8.81 (2.13-36.52) 0.003
TAVI [ n(%)] 7.08 (1.86-27.04) 0.004   
Aortic regurgitation 6m [ n(%)] 2.35 (0.69-8.03) 0.17   
  1. LVDVI = left ventricular end-diastolic volume index; LVSVI = left ventricular end-systolic volume index;; LVMI = left ventricular mass index; LAVI = left atrial volume index; Δ EF = baseline- 6 months ejection fraction; Δ LVDVI = baseline- 6 months LVDVI; Δ LVSVI = baseline- 6 months LVSVI; Δ LVMI = baseline- 6 months LVMI; Δ LAVI = baseline- 6 months LAVI; Δ EAOI = relative increase in EAOI at 6 months; Δ E/e’ = baseline- 6 months E/e’; COPD = chronic obstructive pulmonary disease; PAD = peripheral artery disease; TAVI = transcatheter aortic valve implantation.