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Table 1 Testing of pulmonary vasoreactivity at initial investigation and after six months of PDE-5 inhibitor therapy with right heart catheter

From: Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report

  HR RR mmHg syst/diast (mean) PAP mmHg syst/diast (mean) RA mmHg PCWP mmHg CI l/min/m 2 SV ml/m 2 TPR dyn × sec × cm -5 PVR dyn × sec × cm -5
baseline 103 140/89 (104) 87/37 (56) 28 8 1,9 33 3.178 1.128
baseline sildenafil 96 106/58 (76) 74/14 (26) 13 3 2,2 41 1.290 760
six months sildenafil 96 105/71 (88) 64/27 (43) 8 4 2,6 46 1.453 708
six months vardenafil 102 114/69 (83) 63/25 (40) 6 6 2,6 44 1.403 604
  1. baseline = initial investigation; baseline sildenafil = 90 minutes after first dose of 25 mg sildenafil p.o.; six months sildenafil = after 6 months of therapy with sildenafil; six months vardenafil = 120 minutes after first dose of 10 mg vardenafil p.o. HR = heart rate; RR = blood pressure; PAP = pulmonary arterial pressure; RA = right atrial pressure; PCWP = pulmonary capillary wedge pressure; CI = cardiac index; SV = stroke volume; TPR = total peripheral resistance; PVR = pulmonary vascular resistance.