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Table 2 TCD and cerebral blood flow modifications. MCA: middle cerebral artery. CPB: cardiopulmonary bypass. CBF: cerebral blood flow.

From: Cerebral blood flow during cardiopulmonary bypass in pediatric cardiac surgery: the role of transcranial Doppler – a systematic review of the literature

Author [reference] Journal (Year of Publication) Type of study and Number of patients Main findings
Lindegaard KF [4] Stroke (1987) Observational on 7 adult patients Linear relationship between flow volume and blood velocity in MCA is present.
Weyland A [5] Anesthesiology (1994) Observational on 15 adult patients Linear relationship between flow volume and blood velocity in MCA is present before and after CPB but cannot reliably predict percentage changes in CBF during CPB.
Bishop CCR [6] Stroke (1986) Observational on 17 adult patients Changes in MCA velocity reliably correlate with changes with CBF evaluated with Xenon133
Rosemberg A [7] Pediatric Research (1985) Experimental in newborn lambs Changes in cerebral blood flow velocity are useful qualitative measures of changes in cerebral blood flow
Trivedi U [8] Annals of Thoracic Surgery (1997) Randomized trial on 60 adult patients receiving either α-stat or pH stat management based CPB Measurement of MCA velocity by TCD expressed as relative changes of a pre-CPB level can be used to examine CBF changes during CPB