Journal (Year of Publication)
Type of study and Number of patients
Trivedi U 
Annals of Thoracic Surgery (1997)
Randomized trial on 60 adult patients receiving either α-stat or pH stat management based CPB
A decrease of CBF (evaluated by Xenon-133 and CBFV) is shown during 28° bypass in patients subjected to α-stat management. This is associated with a significant reduction in PaCO2, while there is no reduction in patients subjected to pH-stat management.
Patel RL 
European Journal of Cardiothoracic Surgery (1993)
Randomized protocol on 70 adult patient undergoing α-stat or ph stat CPB
The cerebral extraction ratio for oxygen indicated a degree of mismatch of cerebral perfusion and demand during CPB in both pH-stat and alpha-stat groups. This mismatch was more pronounced in the pH-stat group than in the alpha-stat group, indicating greater disruption in cerebral autoregulation in the former group.
Gruber E 
Anesthesia Analgesia (1999)
Prospective randomized study on 35 neonates and infants managed with different hematocrit values
An inverse relation is present between hematocrit and CBFV during DHCPB
Rodriguez R 
Annals of Thoracic Surgery (2000)
Observational on 124 children
Aorto-venous can impair cerebral perfusion which may be effectively followed by Doppler flow.