Author [reference] | Journal (Year of Publication) | Type of study and Number of patients | Main findings |
---|---|---|---|
Trivedi U [8] | Annals of Thoracic Surgery (1997) | Randomized trial on 60 adult patients receiving either α-stat or pH stat management based CPB | A decrease of CBF (evaluated by Xenon-133 and CBFV) is shown during 28° bypass in patients subjected to α-stat management. This is associated with a significant reduction in PaCO2, while there is no reduction in patients subjected to pH-stat management. |
Patel RL [22] | European Journal of Cardiothoracic Surgery (1993) | Randomized protocol on 70 adult patient undergoing α-stat or ph stat CPB | The cerebral extraction ratio for oxygen indicated a degree of mismatch of cerebral perfusion and demand during CPB in both pH-stat and alpha-stat groups. This mismatch was more pronounced in the pH-stat group than in the alpha-stat group, indicating greater disruption in cerebral autoregulation in the former group. |
Gruber E [23] | Anesthesia Analgesia (1999) | Prospective randomized study on 35 neonates and infants managed with different hematocrit values | An inverse relation is present between hematocrit and CBFV during DHCPB |
Rodriguez R [24] | Annals of Thoracic Surgery (2000) | Observational on 124 children | Aorto-venous can impair cerebral perfusion which may be effectively followed by Doppler flow. |