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Table 5 Miscellaneous. CBFV: cerebral blood flow velocity. DHCPB: deep hypothermic cardiopulmonary bypass.

From: Cerebral blood flow during cardiopulmonary bypass in pediatric cardiac surgery: the role of transcranial Doppler – a systematic review of the literature

Author [reference] Journal (Year of Publication) Type of study and Number of patients Main findings
Trivedi U [8] Annals of Thoracic Surgery (1997) Randomized trial on 60 adult patients receiving either α-stat or pH stat management based CPB A decrease of CBF (evaluated by Xenon-133 and CBFV) is shown during 28° bypass in patients subjected to α-stat management. This is associated with a significant reduction in PaCO2, while there is no reduction in patients subjected to pH-stat management.
Patel RL [22] European Journal of Cardiothoracic Surgery (1993) Randomized protocol on 70 adult patient undergoing α-stat or ph stat CPB The cerebral extraction ratio for oxygen indicated a degree of mismatch of cerebral perfusion and demand during CPB in both pH-stat and alpha-stat groups. This mismatch was more pronounced in the pH-stat group than in the alpha-stat group, indicating greater disruption in cerebral autoregulation in the former group.
Gruber E [23] Anesthesia Analgesia (1999) Prospective randomized study on 35 neonates and infants managed with different hematocrit values An inverse relation is present between hematocrit and CBFV during DHCPB
Rodriguez R [24] Annals of Thoracic Surgery (2000) Observational on 124 children Aorto-venous can impair cerebral perfusion which may be effectively followed by Doppler flow.