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Table 2 Clinical studies that investigated the relation of the spectral tissue Doppler E/E' ratio with maximal exercise tolerance

From: Current clinical applications of spectral tissue Doppler echocardiography (E/E' ratio) as a noninvasive surrogate for left ventricular diastolic pressures in the diagnosis of heart failure with preserved left ventricular systolic function

Reference

Population study

Number of patients

Relation with PVo2

Spectral tissue Doppler index measured at rest

Matsumura79

HCM

85

-0.42* (p < 0.001)

Lateral E/E' ratio

McMahon80

HCM in children

80

-0.74* (p < 0.001)

Septal E/E' ratio

Ha81

HCM

29

-0.47* (p = 0.01)

Septal E/E' ratio

Smart82

Chronic systolic HF

95

-0.31* (p = 0.001)

Average E/E' ratio

Lee83

Permanent atrial fibrillation

73

-0.35† (p = 0.03)

Septal E/E' ratio

Hadano84

Chronic LV systolic dysfunction

53

-0.68* (p < 0.001)

Lateral E/E' ratio

Van de Veire85

CAD and preserved LV systolic function

142

p = 0.005‡

Septal E/E' ratio

Reference

Population study

Number of patients

Relation with METs

Spectral tissue Doppler index measured at rest

Skaluba86

Clinically indicated treadmill exercise

121

-0.68* (p < 0.001)

Septal E/E' ratio

Burgess78

Clinically indicated treadmill exercise

166

-0.37* (p < 0.001)

Septal E/E' ratio

Reference

Population study

Number of patients

Relation with METs

Post-exercise spectral tissue Doppler index

Burgess78

Clinically indicated treadmill exercise

166

-0.44* (p < 0.001)

Septal E/E' ratio

  1. CAD: coronary artery disease; HCM: hypertrophic cardiomyopathy; HF: heart failure; LV: left ventricular; METs: achieved metabolic equivalents; PVo2: peak oxygen consumption during exercise.
  2. *: univariate regression analysis; †: multivariate regression analysis; ‡: analysis of variance for E/E' between quartiles of PVo2.