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Table 4 Clinical studies that investigated the accuracy of the spectral tissue Doppler E/E' for the diagnosis of acute congestive heart failure on admission before tailored therapy.

From: Current clinical applications of spectral tissue Doppler echocardiography (E/E' ratio) as a noninvasive surrogate for left ventricular diastolic pressures in the diagnosis of heart failure with preserved left ventricular systolic function

Reference Population study Number of patients Sensitivity-Specificity Threshold value for E/E'
Dokainish97 NYHA II to IV
LVEF < 50%
76 92% – 72% Average E/E' > 15
Dokainish97 NYHA II to IV
LVEF > 50%
46 79% – 93% Average E/E' > 15
Arques98 Acute dyspnea at rest
LVEF > 45%
70 80% – 94.3%
76.7% – 91.4%
Average E/E' > 11.5
Septal E/E' > 13
Arques99 Acute dyspnea at rest
LVEF > 50%, BNP 100–400 pg/ml
34 88.2% – 76.5%
76.5% – 88.2%
Average E/E' > 10.1
Septal E/E' > 13
Arques100 Acute dyspnea at rest, elderly
LVEF > 50%, atrial fibrillation
41 81.8% – 89.5% Septal E/E' > 13
Arques104 Acute dyspnea
LVEF > 50%, hypertension
40 77.8% – 100% Lateral E/E' > 11
Huang105 Acute dyspnea
LVEF < 50%
-* 70.8% – 100% Average E/E' > 16
Huang105 Acute dyspnea
LVEF > 50%
-* 88.9% – 82.9% Average E/E' > 11
  1. BNP: B-type natriuretic peptide; LVEF: left ventricular ejection fraction;*: overall population of 92 patients.