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Table 4 Clinical studies that investigated the accuracy of the spectral tissue Doppler E/E' for the diagnosis of acute congestive heart failure on admission before tailored therapy.

From: Current clinical applications of spectral tissue Doppler echocardiography (E/E' ratio) as a noninvasive surrogate for left ventricular diastolic pressures in the diagnosis of heart failure with preserved left ventricular systolic function

Reference Population study Number of patients Sensitivity-Specificity Threshold value for E/E'
Dokainish97 NYHA II to IV LVEF < 50% 76 92% – 72% Average E/E' > 15
Dokainish97 NYHA II to IV LVEF > 50% 46 79% – 93% Average E/E' > 15
Arques98 Acute dyspnea at rest LVEF > 45% 70 80% – 94.3% 76.7% – 91.4% Average E/E' > 11.5 Septal E/E' > 13
Arques99 Acute dyspnea at rest LVEF > 50%, BNP 100–400 pg/ml 34 88.2% – 76.5% 76.5% – 88.2% Average E/E' > 10.1 Septal E/E' > 13
Arques100 Acute dyspnea at rest, elderly LVEF > 50%, atrial fibrillation 41 81.8% – 89.5% Septal E/E' > 13
Arques104 Acute dyspnea LVEF > 50%, hypertension 40 77.8% – 100% Lateral E/E' > 11
Huang105 Acute dyspnea LVEF < 50% -* 70.8% – 100% Average E/E' > 16
Huang105 Acute dyspnea LVEF > 50% -* 88.9% – 82.9% Average E/E' > 11
  1. BNP: B-type natriuretic peptide; LVEF: left ventricular ejection fraction;*: overall population of 92 patients.