Table 2 The main cardiovascular cellular and extracellular targets of CT
From: Cancer therapy and cardiotoxicity: The need of serial Doppler echocardiography
Target Damage | Kind of CT |
|---|---|
Endothelial cells | Anthracyclines, Cyclophosphamide, 5-fluorouracil (TNF-α induced apoptosis), Monoclonal antibodies, Radiation therapy |
Cardiomyocytes | Anthracyclines (atrophy and apoptosis), Cyclophosphamide, Cisplatin, 5-fluorouracil, Monoclonal antibodies (mitochondrial apoptosis), Radiation therapy |
Smooth muscle cells | Anthracyclines Cytarabine, Cisplatin, 5-fluorouracil, Cytokines, Arsenic trioxide, Radiation therapy |
Extracellular matrix | Anthracyclines, Cisplatin, 5-fluorouracil, Radiation therapy |