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Table 3 Sensor-monitored force-frequency relation in normal and diseased hearts

From: Post-exercise contractility, diastolic function, and pressure: Operator-independent sensor-based intelligent monitoring for heart failure telemedicine

Clinical status

Force-Frequency Relation (FFR)

Diastolic time-frequency relation

S2-frequency relation

Normal

Upsloping FFR

systolic/diastolic time ratio < 1

Normal upsloping

 

Normal recovery

Normal recovery

Recovery undershoot

Acute ischemia

Acute biphasic FFR

Acute systolic/diastolic time ratio > 1

Acute S2 blunting

 

Recovery overshoot

Recovery overshoot

Recovery overshoot

CHF worsening ↓

1- Blunted FFR slope

  

↓↓

2- From upsloping to biphasic FFR

Systolic/diastolic time ratio > 1 at lower HR

S2 blunting

↓↓↓

3- Lower critical HR in biphasic FFR

  
 

- Recovery overshoot

Recovery overshoot

 

CHF improving ↑↑↑

3- Upsloping FFR

  

↑↑

2- From biphasic to upsloping FFR

Systolic/diastolic time ratio > 1 at higher HR

Upsloping S2

↑

1- Higher critical HR in biphasic FFR

  
 

- Normal recovery

 

Upsloping S2

Hypertension/diastolic failure

Blunted FFR

Systolic/diastolic time ratio > 1 at lower HR

Steeper S2 curve

 

Recovery overshoot

Recovery overshoot

Recovery overshoot

Atrial fibrillation

Preceding and pre-preceding interval FFR dependence

Systolic/diastolic time ratio scattering

S2 scattering

  1. S2 = Second heart sound peak amplitude vibrations; HR = Heart Rate; FFR recovery overshoot = a relative increase in recovery FFR of more than 10% with respect to the exercise value