Usefulness of NT-pro BNP monitoring to identify echocardiographic responders following cardiac resynchronization therapy

Table 2 Baseline and late post-CRT Echocardiographic data.

Variables	All patients (n = 42)	Responders (n = 29, 69%)	Non Responders (n = 13, 31%)	P Value
LV geometry and function
LV end-systolic Volume, ml
Baseline	177 ± 65	175 ± 64	189 ± 62	0.49
Late post-CRT	155 ± 67	133 ± 57*	198 ± 67	0.0017
LV end-diastolic Volume, ml
Baseline	213 ± 69	209 ± 67	228 ± 67	0.40
Late post-CRT	201 ± 73	181 ± 66*	239 ± 72*	0.01
LV stroke Volume, ml
Baseline	42 ± 13	39 ± 10	50 ± 13	0.0048
Late post-CRT	51 ± 11	51 ± 9*	49 ± 14	0.65
LV ejection fraction, %
Baseline	19 ± 7	18 ± 7	19 ± 7	0.75
Late post-CRT	24 ± 9	27 ± 9*	18 ± 6	0.0025
Wall Motion Score Index
Baseline rest	3.5 ± 0.4	3.4 ± 0.4	3.6 ± 0.2	0.29
Baseline dobutamine	3.1 ± 0.4	3 ± 0.4*	3.3 ± 0.4*	0.038
Contractile Reserve, n (%)	30 (71)	24 (83)	6 (46)	0.02
Mitral Regurgitation
Effective orifice Area, mm²
Baseline	18 ± 13	18 ± 12	17 ± 14	0.73
Late post-CRT	10 ± 11	5 ± 5*	19 ± 15	< 0.0001
Regurgitant Volume, ml
Baseline	29 ± 26	31 ± 29	25 ± 19	0.54
Late post-CRT	17 ± 17	11 ± 13*	29 ± 19	0.0009
Severe Mitral Regurgitation, n (%)
Baseline	19 (45)	12 (41)	7 (54)	0.45
Late post-CRT	10 (61)	2 (7)*	8 (61)	0.0005
Asynchronism
Interventricular, ms	46 ± 27	46 ± 30	45 ± 22	0.92
Intraventricular, ms	85 ± 25	85 ± 25	85 ± 27	0.93

LV indicates left-ventricular and CRT, cardiac resynchronisation therapy. * significant difference (p < 0.05) between baseline and late post-CRT or between rest and dobutamine data; severe mitral regurgitation is defined as an effective orifice area ≥ 20 mm².

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