Impact of Chronic Kidney Disease on the Presence and Severity of Aortic Stenosis in Patients at High Risk for Coronary Artery Disease

Table 1 Clinical Characteristics of Study Subjects

	Non-AS (n = 79)	AS (n = 41)
Demographics
Mean age, years	65 ± 12	72 ± 12*
Female gender, %	11	34*
Height, cm	165 ± 8	157 ± 9*
Body weight, kg	65 ± 12	58 ± 10*
Systolic blood pressure, mmHg	129 ± 21	137 ± 28
Heart rate, beats/min	67 ± 12	69 ± 14
Medical history
Hypertension, %	70	78
Diabetes mellitus, %	34	39
Dyslipidemia, %	67	71
Current smoking, %	46	20*
Coronary artery disease, %	73	85
Chronic kidney disease, %	41	76*
Medication use
Beta blocker, %	27	29
Calcium channel blocker, %	39	44
ACEI/ARB, %	56	66
Diuretics, %	20	20
Statin, %	46	46
Measurements
eGFR, ml/min/1.73 m²	64 ± 23	53 ± 18*
Hemoglobin, g/dl	13.2 ± 2.0	12.8 ± 1.9
Calcium, mg/dl	9.4 ± 0.6	9.5 ± 0.6
Phosphate, mg/dl	3.4 ± 0.6	3.4 ± 0.6
Total cholesterol, mg/dl	185 ± 44	182 ± 30
HDL-cholesterol, mg/dl	50 ± 18	50 ± 14
LDL-cholesterol, mg/dl	108 ± 36	105 ± 24
Triglyceride, mg/dl	135 ± 64	131 ± 55
Hemoglobin A1C, %	6.0 ± 1.0	6.1 ± 0.8
C-reactive protein, mg/dl	0.20 ± 0.28	0.32 ± 0.79

AS: aortic stenosis; ACEI: angiotensin converting enzyme inhibitor; ARB: angiotensin receptor blocker; eGFR: estimated glomerular filtration rate; HDL: high density lipoprotein; LDL: low density lipoprotein. *P < 0.05 versus non-AS.

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