Figure 2From: The role of renin angiotensin system antagonists in the prevention of doxorubicin and trastuzumab induced cardiotoxicityTimeline for drugs administered to mice in each group. Mice received prophylactic treatment with Aliskiren (50Â mg/kg), Perindopril (3Â mg/kg) or Valsartan (10Â mg/kg) in drinking water daily. Prophylactic treatment was started 2Â weeks prior to chemotherapy with DOX, TRZ and DOX + TRZ and was continued for 13Â weeks. DOX (4Â mg/kg), TRZ (4Â mg/kg) and DOX + TRZ (4Â mg/kg) was administered by weekly intraperitoneal injection for a total of 5Â weeks. Cardiac function was monitored by echocardiography on a weekly basis for 13Â weeks.Back to article page