Timeline for drugs administered to mice in each group. Mice received prophylactic treatment with Aliskiren (50 mg/kg), Perindopril (3 mg/kg) or Valsartan (10 mg/kg) in drinking water daily. Prophylactic treatment was started 2 weeks prior to chemotherapy with DOX, TRZ and DOX + TRZ and was continued for 13 weeks. DOX (4 mg/kg), TRZ (4 mg/kg) and DOX + TRZ (4 mg/kg) was administered by weekly intraperitoneal injection for a total of 5 weeks. Cardiac function was monitored by echocardiography on a weekly basis for 13 weeks.