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Table 1 Patient Demographics, echocardiographic parameters and Invasive Hemodynamics

From: Grading diastolic function by echocardiography: hemodynamic validation of existing guidelines

 

Normal

Grade 1

Grade 2

Grade 3

P value

N

55

132

156

117

-

Age

51.4 ± 13.1

66.0 ± 12.0

62.7 ± 11.5

64.8 ± 14.4

<0.001

Male Gender

35/55 (63.6 %)

85/132 (64.4 %)

95/156 (60.9 %)

66/117 (56.4 %)

0.54

White Race

42/53 (79.2 %)

105/130 (80.8 %)

122/153 (79.7 %)

89/115 (77.4 %)

0.93

Cath indication

    

<0.001

 CAD

45 (81.8 %)

62 (47.0 %)

103 (66.0 %)

37 (31.6%)

 

 Aortic stenosis

0 (0.0 %)

21 (15.9 %)

12 (7.7 %)

20 (17.1 %)

 

 LV dysfunction

6 (10.9 %)

28 (21.2 %)

26 (16.7 %)

38 (32.5%)

 

 LV hypertrophy

3 (5.5 %)

21 (15.9 %)

13 (8.3 %)

18 (15.4%)

 

 Other

1 (1.8 %)

0 (0.0 %)

2 (1.3 %)

4 (3.4 %)

 

BMI

28.4 (23.1-32.3)

28.8 (25.2-31.2)

27.3 (24.6-31.2)

28.9 (25.3-32.9)

0.39

BNP

34 (18-117)

77 (30-180)

108 (29-298)

210 (83-556)

<0.001

LVEF

58 % (53-64 %)

60 % (50-66 %)

57 % (51-63 %)

51 % (38-60 %)

<0.001

LA volume index

23.7 (18.4-30.7)

26.1 (18.7-34.2)

26.5 (21.2-36.2)

35.4 (25.3-47.4)

<0.001

E/A ratio

1.5 (1.2-1.8)

0.70 (0.61-0.79)

1.0 (0.8-1.2)

1.2 (0.9-2.0)

0.011

E/e’ ratio

7.0 (6.3-8.8)

8.3 (6.8-11.5)

10.4 (9.2-11.9)

15.7 (12.7-20.5)

<0.001

DT

182 (161-209)

250 (216-296)

190 (174-220)

160 (145-207)

<0.001

Systolic BP

127 (119-146)

139 (126-159)

140 (124-156)

138 (119-156)

0.012

Tau

43.8 (35.7-53.5)

51.3 (41.5-60.2)

44.8 (37.6-54.4)

47.5 (38.9-59.6)

0.003

LVEDP

16.0 (10.0-20.0)

14.0 (11.0-18.0)

14.0 (10.0-18.0)

18.0 (12.0-24.0)

<0.001

  1. Data are presented as mean ± standard deviation where normally distributed or median (25th to 75th percentile). P values are for ANOVA across diastolic function grades
  2. BMI body mass index, BNP B-type natriuretic peptide, LVEF left ventricular ejection fraction, LA left atrium, DT deceleration time, IVRT isovolumic relaxation time, SBP systolic blood pressure, DBP diastolic blood pressure, LVEDP left ventricular end-diastolic pressure, CAD coronary artery disease