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Table 3 Echocardiographic and arterial stiffness parameters across CKD stages

From: Left ventricular twist mechanics and its relation with aortic stiffness in chronic kidney disease patients without overt cardiovascular disease

 

CKD stage 1/2

CKD stage 3

CKD stage 4/5

p valuea

Adjusted p valueb

Simpsons biplane EF (%)

63.7 ± 5.5

62.3 ± 4.9

62.5 ± 4.9

0.617

0.838

LVMI (g/m2)

60.5 ± 20

70 ± 19.8

75.6 ± 24.1

0.003â–ª

0.085â–ª

Concentric remodelling (%)RWT > 0.42

31

52.6

72.3

<0.001‡▪•

<0.001‡▪•

E/e’ (average)

6.96 ± 2.25

9.41 ± 3.87

9.92 ± 3.96

<0.001‡ ▪

0.013‡ ▪

TDI S’ - septal (cm/s)

11 ± 2.7

10.6 ± 3.7

9.1 ± 2.3

0.02▪•

0.03▪•

LV Twist (°)

18.5 ± 4.4

19.9 ± 5.4

24.6 ± 5.4

<0.001‡▪•

<0.001‡▪•

PWV(m/s)

7.7 ± 2

10.3 ± 3.3

12.5 ± 4.2

<0.001‡▪•

0.001‡▪•

  1. LVEF left ventricular ejection fraction; LVMI left ventricular mass index; RWT regional wall thickness; LV left ventricular; PWV pulse wave velocity
  2. aStatistically significant difference between: ‡CKD stage 1/2 and CKD stage 3, ▪CKD stage 1/2 and CKD stage 4/5, •CKD stage 3 and CKD stage 4/5
  3. bAdjusted for age, gender, diabetes, SBP, BMI, treated hyperlipidaemia, eGFR and family history of ischaemic heart disease