|
Variables
|
Chagas
|
Controls
|
|---|
|
Ch1A (n = 8)
|
Ch1B (n = 13)
|
Ch2 (n = 17)
|
Ch3 (n = 9)
|
C1 (n = 58)
|
C2 (n = 7)
|
C3 (n = 19)
|
|---|
|
LA (mm)a
|
34.4 ± 2.3
|
32.2 ± 4.7
|
40.7 ± 4.1
|
46.6 ± 6.5
|
33.6 ± 3.2
|
37.9 ± 6.8
|
44.1 ± 5.1
|
|
LVDD (mm)a
|
47.4 ± 3.9
|
47.1 ± 4.2
|
62.4 ± 5.7
|
74.9 ± 5.8c
|
46.7 ± 4.5
|
50.7 ± 7.6
|
67.0 ± 4.9
|
|
LVSD(mm)a
|
31.3 ± 3.9
|
33.5 ± 4.8
|
50.5 ± 7.2
|
66.1 ± 5.7
|
30.5 ± 3.2
|
45.9 ± 7.0
|
59.5 ± 5.1
|
|
LVFS (%)a
|
34.3 ± 3.1
|
33.3 ± 4.9
|
19.3 ± 6.0
|
11.2 ± 3.7
|
35.2 ± 2.6
|
19.0 ± 9.4
|
11.2 ± 2.6
|
|
LVEDV (ml)a
|
82.5 ± 24.6d
|
74.0 ± 29.8
|
149.5 ± 37.0
|
262.0 ± 61.7
|
108.7 ± 28.2
|
147.1 ± 67.8
|
216.4 ± 63.4
|
|
LVESV (ml)a
|
29.5 ± 11.8
|
38.5 ± 15.3
|
84.6 ± 24.0
|
191.6 ± 43.8
|
39.6 ± 13.2
|
87.0 ± 45.8
|
167.1 ± 49.7
|
|
LVEF (%)a
|
65.0 ± 4.3
|
61.7 ± 5.5
|
43.8 ± 6.6
|
26.6 ± 3.9
|
64.3 ± 4.6
|
42.1 ± 6.0
|
23.0 ± 6.1
|
|
Diast. Func.e
|
|
Normal
|
5 (62.5 %)
|
9 (69.7 %)
|
1 (5.9 %)
|
0 (0 %)
|
54 (93.1 %)
|
2 (28.6 %)
|
0 (0 %)
|
|
Grade I
|
3 (37.5 %)e
|
4 (30.8 %)e
|
11 (64.7 %)
|
5 (55.6 %)
|
4 (6.9 %)
|
5 (71.4 %)
|
8 (42.1 %)
|
|
Grade II
|
0 (0 %)
|
0 (0 %)
|
5 (29.4 %)
|
4 (44.4 %)
|
0 (0 %)
|
0 (0 %)
|
5 (26.3 %)
|
|
Grade III
|
0 (0 %)
|
0 (0 %)
|
0 (0 %)
|
0 (0 %)
|
0 (0 %)
|
0 (0 %)
|
1 (5.3 %)
|
|
Grade IV
|
0 (0 %)
|
0 (0 %)
|
0 (0 %)
|
0 (0 %)
|
0 (0 %)
|
0 (0 %)
|
5 (26.3 %)
|
|
E Vel (m/s)a
|
0.73 ± 0.17
|
0.78 ± 0.15
|
0.65 ± 0.26
|
0.79 ± 0.34
|
0.82 ± 0.16
|
0.61 ± 0.16
|
0.76 ± 0.24
|
|
E DT (ms)a
|
240.6 ± 37.3f
|
214.5 ± 36.3
|
274.6 ± 81.3
|
233.6 ± 60.5
|
190.8 ± 33.3
|
238.6 ± 61.8
|
200.9 ± 107.4
|
|
A Vel (m/s)a
|
0.71 ± 0.16g
|
0.69 ± 0.17g
|
0.67 ± 0.27
|
0.69 ± 0.18
|
0.48 ± 0.12
|
0.71 ± 0.19
|
0.60 ± 0.33
|
|
S’ Vel (cm/s)a
|
0.06 ± 0.01h
|
0.05 ± 0.01h
|
0.05 ± 0.01
|
0.04 ± 0.01
|
0.08 ± 0.02
|
0.05 ± 0.01
|
0.03 ± 0.01
|
|
E’ Vel (cm/s)a
|
0.06 ± 0.02i
|
0.08 ± 0.02i
|
0.05 ± 0.01
|
0.03 ± 0.01
|
0.11 ± 0.02
|
0.07 ± 0.01
|
0.04 ± 0.02
|
|
A’ Vel (cm/s)a
|
0.09 ± 0.03
|
0.08 ± 0.02
|
0.07 ± 0.02
|
0.06 ± 0.02
|
0.09 ± 0.02
|
0.06 ± 0.01
|
0.04 ± 0.02
|
|
E/E’a
|
12.0 ± 4.3g
|
11.8 ± 5.3g
|
13.4 ± 4.7
|
23.9 ± 11.1
|
7.9 ± 1.7
|
9.8 ± 2.5
|
23.4 ± 11.0
|
|
MR Gradeb
|
|
Absent/Trivial
|
6 (75.0 %)
|
9 (69.2 %)
|
4 (23.5 %)
|
0 (0 %)
|
55 (94.8 %)
|
2 (28.6 %)
|
1 (5.3 %)
|
|
Mild
|
2 (25.0 %)j
|
4 (30.8 %)j
|
9 (52.9 %)
|
3 (33.3 %)
|
3 (5.2 %)
|
4 (57.1 %)
|
13 (68.4 %)
|
|
Moderate
|
0 (0 %)
|
0 (0 %)
|
3 (17.6 %)
|
2 (22.2 %)
|
0 (0 %)
|
1 (14.3 %)
|
4 (21.1 %)
|
|
Severe
|
0 (0 %)
|
0 (0 %)
|
1 (5.9 %)
|
4 (44.4 %)
|
0 (0 %)
|
0 (0 %)
|
1 (5.3 %)
|
- aContinuous numeric variables expressed as mean ± SD. bOrdinal variables expressed as number of patients (percentage). LA, left atrium; LVDD, left ventricular diastolic diameter, LVSD, left ventricular systolic diameter; LVFS, left ventricular fractional shortening; LVEDV, end-diastolic volume of the left ventricle; LVESV, end-systolic volume of the left ventricle; LVEF, left ventricular ejection fraction; E Vel, E wave velocity, TD E, deceleration time of E wave; A Vel, A wave velocity; S' Vel, S’ wave velocity; E’ Vel, E’ wave velocity; MR degree, degree of mitral regurgitation
- cStudent t-test, p = 0.01; vs. C3
- dTukey test, p = 0.04, vs. C1
- eFisher’s exact test; Ch1A and Ch1B, p = 0.03; vs. C1
- fTukey test, p = 0.01, vs. C1
- gTukey; Ch1A and Ch1B, p < 0.05, vs. C1
- hTukey; Ch1A and Ch1B, p < 0.01, vs. C1
- iTukey; Ch1A and Ch1B, p < 0.05, vs. C1
- jTukey; Ch1A and Ch1B, p = 0.01, vs. C1
