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Table 1 Patients with limited exercise vs. good exercise capacity (6-MWT distance)

From: Different determinants of exercise capacity in HFpEF compared to HFrEF

Variable All patients 6MWT > 300 m 6MWT ≤ 300 m P value
  (n = 111) (n = 70) (n = 41)  
Clinical and biochemical data
 Age (years) 63 ± 10 61 ± 10 66 ± 9 0.008
 Female (%) 47 41 56 0.135
 Smoking (%) 31.5 30 34 0.676
 Diabetes (%) 28 20 41 0.027
 Arterial hypertension (%) 69.4 68.6 70.7 0.835
 Waist/hips ratio 0.97 ± 0.06 0.96 ± 0.06 0.98 ± 0.05 0.064
 BMI (kg/m2) 28.6 ± 4.1 28.7 ± 4.2 28.4 ± 3.8 0.764
 BSA (m2) 1.13 ± 0.2 1.15 ± 0.1 1.08 ± 0.1 0.067
 Fasting glucose (mmol/L) 6.8 ± 2.8 6.4 ± 2.4 7.9 ± 2.9 0.009
 Total cholesterol (mmol/L) 4.9 ± 1.2 4.9 ± 1.1 4.8 ± 1.2 0.439
 Triglycerides (mmol/L) 1.7 ± 0.7 1.7 ± 0.7 1.6 ± 0.8 0.747
 Creatinine (μmol/L) 96 ± 46 98 ± 56 93 ± 21 0.527
 Hemoglobin (g/dl) 12.7 ± 1.8 12.8 ± 1.6 12.3 ± 2.0 0.166
 NT-ProBNP (pg/mL 1178 ± 1635 970 ± 1286 1534 ± 2072 0.124
 Baseline heart rate (beats/min) 74 ± 16 71 ± 15 80 ± 13 0.004
Echocardiographic data
 Ejection fraction (%) 47 ± 15 48 ± 14 45 ± 15 0.409
 IVSd (cm) 1.1 ± 0.2 1.1 ± 0.2 1.11 ± 0.1 0.923
 Left atrium (cm) 4.4 ± 0.8 4.2 ± 0.7 4.8 ± 0.9 0.001
 LV EDD (cm) 5.8 ± 1.0 5.7 ± 0.8 5.9 ± 1.1 0.319
 LV ESD (cm) 4.4 ± 1.2 4.2 ± 1.1 4.5 ± 1.3 0.281
 Lateral MAPSE (cm) 1.15 ± 0.4 1.2 ± 0.4 1.05 ± 0.3 0.051
 Septal MAPSE (cm) 1.0 ± 0.3 1.0 ± 0.3 0.9 ± 0.2 0.054
 TAPSE (cm) 2.15 ± 0.5 2.2 ± 0.4 2.1 ± 0.5 0.466
 LVPWd (cm) 1.05 ± 0.15 1.05 ± 0.2 1.05 ± 0.1 0.960
 LVM (g) 266 ± 85 260 ± 75 279 ± 101 0.324
 LVMI (g/m2.7) 58 ± 21 53 ± 16 67 ± 26 0.006
 E/A ratio 1.05 ± 0.7 1.0 ± 0.7 1.1 ± 0.8 0.414
 E wave DT 174 ± 49 178 ± 50 167 ± 44 0.228
 Filling time (ms) 414 ± 132 434 ± 141 376 ± 104 0.019
 IVRT (ms) 126 ± 41 131 ± 42 110 ± 34 0.037
 PA acceleration time (ms) 110 ± 24 114 ± 23 100 ± 21 0.006
 E/e’ ratio 11 ± 5.9 10 ± 4.1 13 ± 8.0 0.053
 Lateral e’ (cm/s) 6.1 ± 2.1 6.1 ± 2.4 6.0 ± 2.6 0.817
 Lateral a’(cm/s) 7.9 ± 3.6 8.1 ± 3.7 7.5 ± 3.5 0.461
 Lateral s’ (cm/s) 5.3 ± 1.6 5.5 ± 1.5 4.9 ± 1.6 0.101
 Septal e’ (cm/s) 4.9 ± 2.2 5.1 ± 2.2 4.6 ± 2.1 0.312
 Septal a’ (cm/s) 7.15 ± 2.3 7.5 ± 2.4 6.4 ± 1.8 0.018
 Septal s’ (cm/s) 4.4 ± 1.5 4.6 ± 1.6 4.0 ± 1.0 0.023
 Right e’ (cm/s) 8.7 ± 3.0 8.9 ± 3.1 8.3 ± 2.7 0.305
 Right a’ (cm/s) 12.5 ± 4.4 12.7 ± 4.3 11.8 ± 4.3 0.333
 Right s’ (cm/s) 8.8 ± 3.0 9.8 ± 2.8 8.0 ± 3.2 0.086
 LAV max (ml) 73 ± 35 68 ± 26 80 ± 47 0.218
 LAV min (ml) 40 ± 29 35 ± 20 49 ± 38 0.067
 LA EF (%) 47 ± 18 49 ± 17 45 ± 16 0.314
  1. LV left ventricle, EDD end-diastolic dimension, ESD end-systolic dimension, DT deceleration time, FT filling time, ET Ejection time, HR heart rate, IVSd interventricular septum in diastole, LVPWd left ventricular posterior wall in diastole, MAPSE mitral annular plane systolic excursion, TAPSE tricuspid annular plane systolic excursion, PA pulmonary artery, A atrial diastolic velocity, E early diastolic filling velocity, e’ early diastolic myocardial velocity, s’ systolic myocardial velocity, LA left atrium, LAV max left atrial maximal volume, LAV min left atrial minimal volume, LA EF left atrial emptying fraction, LVM left ventricular mass, LVMI left ventricular mass index