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Table 2 Comparison of patients’ data between patients HFpEF and HFrEF

From: Different determinants of exercise capacity in HFpEF compared to HFrEF

Variable HFpEF HFrEF P value
  (n = 55) (n = 56)  
Clinical and biochemical data
 Age (years) 63 ± 6.8 62 ± 12 0.767
 Body-mass index (kg/m2) 29 ± 4 28 ± 3.6 0.130
 Waist/hips ratio 0.96 ± 0.06 0.96 ± 0.06 0.996
 Fasting glucose (mmol/L) 7.1 ± 3.1 6.7 ± 2.3 0.462
 Total cholesterol (mmol/L) 5.1 ± 1.1 4.7 ± 1.1 0.054
 Triglycerides (mmol/L) 1.8 ± 0.7 1.5 ± 0.7 0.137
 Creatinine (μmol/L) 87 ± 16 105 ± 63 0.052
 Hemoglobin (g/dL) 12.8 ± 1.9 12.4 ± 1.5 0.078
 Baseline heart rate (beats/min) 70 ± 15 79 ± 15 0.005
 NT-ProBNP (pg/mL) 681 ± 1280 1665 ± 1801 0.001
 6-min walk distance (m) 339 ± 106 282 ± 119 0.010
 PPV of 6-min walk distance (%) 56 ± 19 45 ± 20 0.004
Echocardiographic data
 IVSd (cm) 1.1 ± 0.1 1.1 ± 0.2 0.666
 Left atrium (cm) 4.2 ± 0.8 4.6 ± 0.7 0.004
 LV EDD (cm) 5.2 ± 0.7 6.3 ± 0.9 <0.001
 LV ESD (cm) 3.5 ± 0.7 5.1 ± 1 <0.001
 EDV (ml) 135 ± 44 213 ± 67 <0.001
 ESV (ml) 56 ± 8.7 140 ± 52 <0.001
 LV EF (%) 59.6 ± 8.7 35 ± 7.5 <0.001
 Lateral MAPSE (cm) 1.27 ± 0.3 1.02 ± 0.4 0.001
 Septal MAPSE (cm) 1.14 ± 0.2 0.85 ± 0.2 <0.001
 TAPSE (cm) 2.3 ± 0.4 2.1 ± 0.5 0.062
 LVPWd (cm) 1.05 ± 0.2 1.06 ± 0.2 0.688
 E/A ratio 0.81 ± 0.3 1.3 ± 0.9 0.001
 LVM (g) 224 ± 69 310 ± 77 <0.001
 LVMI (g/m2.7) 50 ± 16 67 ± 23 <0.001
 E wave DT 189 ± 44 159 ± 49 0.002
 Filling time (ms) 454 ± 147 372 ± 99 0.001
 IVRT (ms) 122 ± 39 130 ± 43 0.407
 PA acceleration time (ms) 118 ± 20 101 ± 23 <0.001
 E/e’ ratio 9.4 ± 4.7 13.5 ± 6.4 0.001
 Lateral e’ (cm/s) 6.7 ± 2.6 5.3 ± 2.2 0.009
 Lateral a’ (cm/s) 8.6 ± 3.3 7.1 ± 3.8 0.051
 Lateral s’ (cm/s) 5.7 ± 1.3 4.8 ± 1.7 0.006
 Septal e’ (cm/s) 5.7 ± 2.5 4.0 ± 1.1 <0.001
 Septal a’ (cm/s) 7.9 ± 2.1 6.2 ± 2.0 <0.001
 Septal s’ (cm/s) 4.9 ± 1.6 3.8 ± 0.9 <0.001
 Right e’ (cm/s) 9.4 ± 3.2 7.9 ± 2.4 0.012
 Right a’ (cm/s) 12.7 ± 4.5 12.2 ± 4.2 0.593
 Right s’ (cm/s) 9.1 ± 3.1 8.3 ± 2.7 0.187
LAV max 62 ± 23 83 ± 57 0.005
LAV min 29 ± 18 51 ± 34 <0.001
 LA EF (%) 53 ± 15 43 ± 18 0.012
  1. LV left ventricle, EDD end-diastolic dimension, ESD end-systolic dimension, DT deceleration time, FT filling time, ET Ejection time, HR heart rate, IVSd interventricular septum in diastole, LVPWd left ventricular posterior wall in diastole, MAPSE mitral annular plane systolic excursion, TAPSE tricuspid annular plane systolic excursion, PA pulmonary artery, A atrial diastolic velocity, E early diastolic filling velocity, e’ early diastolic myocardial velocity, s’ systolic myocardial velocity, LA left atrial, LAV max left atrial maximal volume, LAV min left atrial minimal volume, LA EF left atrial eemptying fraction, LVM left ventricular mass, LVMI left ventricular mass index, PPV percentage of the predicted value