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Table 3 Factors associated with good response to cardiac resynchronization therapy (univariate and multivariate regression analyses)

From: Pilot study using 3D–longitudinal strain computation in a multi-parametric approach for best selecting responders to cardiac resynchronization therapy

  Univariable OR (95% IC) p Value Multivariable OR (95% IC) P value
Female 5.33 (1.03–27.5) 0.046* 1.64 (0.01–14.7) 0.657
Non-ischemic etiology 3.25 (0.87–12.1) 0.079* 5.33 (0.92–31.1) 0.063Ŧ
LBBB morphology 1.05 (0.23–4.83) 0.948   
QRS > 150 ms 1.58 (0.32–7.76) 0.572   
GLS 1.44 (1.11–1.89) 0.007* 1.22 (0.01–1.77) 0.223
Atrioventricular dyssynchrony 0.89 (0.26–3.09) 0.853   
IVMD >40 ms 10.3 (2.12–50.3) 0.004* 4.35 (0.53–36) 0.172
LVPEI 1.02 (0.99–1.04) 0.189   
DTI septo-lateral delay 1.01 (0.99–1.02) 0.1   
Septal Flash 14.1 (3.08–64.9) 0.001* 14.1 (3.08–64.9) 0.001Ŧ
SDt,peak 49.1 (−) 0.604   
SDIL,peak 18 (1.94–167) 0.011* 12.1 (0.81–180) 0.078Ŧ
DiffInt 0.55 (0.15–1.97) 0.354   
MSDI 41.8 (0.42–4200) 0.113   
  1. DiffInt average of 17 LV segments of the difference between IL,avc and IL,peak for each 17 LV segments, DTI doppler tissue imaging, GLS global strain longitudinal, IVMD intraventricular mechanical delay, LbBB left bundle branch block morphology, LVPEI left ventricular pre-ejection interval, MSDI Maximal Difference between Strain peak Instants, SD standard deviation, SDI L,peak standard deviation of the integrals of strain signals I L,peak of 17 LV segments, t peak time to strain peak. *All potential factors of positive response to CRT identified from the univariate analyses with a P value <0,1 were used in the multivariate logistic regression. Ŧ Variable with a P value <0,1 in the multivariate model were considered to be possible contributors of positive response of CRT