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Table 3 Factors associated with good response to cardiac resynchronization therapy (univariate and multivariate regression analyses)

From: Pilot study using 3D–longitudinal strain computation in a multi-parametric approach for best selecting responders to cardiac resynchronization therapy

 

Univariable OR (95% IC)

p Value

Multivariable OR (95% IC)

P value

Female

5.33 (1.03–27.5)

0.046*

1.64 (0.01–14.7)

0.657

Non-ischemic etiology

3.25 (0.87–12.1)

0.079*

5.33 (0.92–31.1)

0.063Ŧ

LBBB morphology

1.05 (0.23–4.83)

0.948

  

QRS > 150 ms

1.58 (0.32–7.76)

0.572

  

GLS

1.44 (1.11–1.89)

0.007*

1.22 (0.01–1.77)

0.223

Atrioventricular dyssynchrony

0.89 (0.26–3.09)

0.853

  

IVMD >40 ms

10.3 (2.12–50.3)

0.004*

4.35 (0.53–36)

0.172

LVPEI

1.02 (0.99–1.04)

0.189

  

DTI septo-lateral delay

1.01 (0.99–1.02)

0.1

  

Septal Flash

14.1 (3.08–64.9)

0.001*

14.1 (3.08–64.9)

0.001Ŧ

SDt,peak

49.1 (−)

0.604

  

SDIL,peak

18 (1.94–167)

0.011*

12.1 (0.81–180)

0.078Ŧ

DiffInt

0.55 (0.15–1.97)

0.354

  

MSDI

41.8 (0.42–4200)

0.113

  
  1. DiffInt average of 17 LV segments of the difference between IL,avc and IL,peak for each 17 LV segments, DTI doppler tissue imaging, GLS global strain longitudinal, IVMD intraventricular mechanical delay, LbBB left bundle branch block morphology, LVPEI left ventricular pre-ejection interval, MSDI Maximal Difference between Strain peak Instants, SD standard deviation, SDI L,peak standard deviation of the integrals of strain signals I L,peak of 17 LV segments, t peak time to strain peak. *All potential factors of positive response to CRT identified from the univariate analyses with a P value <0,1 were used in the multivariate logistic regression. Ŧ Variable with a P value <0,1 in the multivariate model were considered to be possible contributors of positive response of CRT