Accurate assessment of LV function using the first automated 2D-border detection algorithm for small animals - evaluation and application to models of LV dysfunction

Table 2 Phenotypic characteristics of pathophysiological small animal models

Species	Modell	Strain	Age (wks)	HW (mg)	BW (g)	HW/ BW-ratio	Blood Glucose (mg/dl)	Other
Mouse	Ctrl	Ncor1^tm1Anh/J	20	150.5 ± 10.1 (n = 4)	33.1 ± 2.3	4.46 ± 0.1 (n = 4)	163 ± 15	–
	Type I DM	Ncor1^tm1Anh/J	20	141.5 ± 17.7 (n = 2)	28.3 ± 2.6	5.34 ± 0.2 (n = 2)	537 ± 101	–
	Ctrl	db/db+	20	158.2 ± 2.6	32.2 ± 0.6	4.92 ± 0.1	146 ± 23.9	–
	Type II DM	db+/db+	20	124.8 ± 1.9	30.4 ± 1.7	3.88 ± 0.2	514 ± 68.6	–
	Ctrl	129/Sv	8–10	113.7 ± 2.8^a	26.8 ± 1.7^a	4.24 ± 0.1^a	156 ± 8^a	–
	Iso	129/Sv	8–10	109.3 ± 2.6^a	26.6 ± 1.8^a	4.11 ± 0.1^a	145 ± 6^a	–
	Ctrl	C57BL/6J	18–19	123.0 ± 8.3	28.0 ± 0.3	4.40 ± 0.1	192.7	Gradient P^b
	Ctrl	C57BL/6J	18–19	123.0 ± 8.3	28.0 ± 0.3	4.40 ± 0.1	±24.7	−2.17 ± 1.1
	TAC	C57BL/6J	18–19	160.3 ± 29.1	28.9 ± 0.3	5.72 ± 0.3	192.2	Gradient P^b
	TAC	C57BL/6J	18–19	160.3 ± 29.1	28.9 ± 0.3	5.72 ± 0.3	±40.6	32.22 ± 3.2
Rats	Ctrl	tetO-shIR	18	–	427 ± 6.8	–	108.5 ± 1.5	–
	TetO	tetO-shIR	26	–	404 ± 5.3	–	427.5 ± 23	–
	mRen	mRen27	26	–	438 ± 12.7	–	117 ± 2.5	–
	TetO/mRen	mRen27/tetO-shIR	26	–	345 ± 12.9	–	309 ± 25.1	–
	Ctrl	Sprague Dawley	7	–	180 ± 7.4	–	–	–
	dTGR	female:TGR(hRen)L10 J	7	–	170 ± 2.8	–	–	–
	dTGR	male:TGR(hAogen)L162 3

HW Heart weight, BW Body weight, HW/BW-ratio heart weight/Bodyweight-ratio. ^aData published previously in [13]. ^bData published previously in [7]. Gradient P assessing the degree of aortic stenosis was calculated from velocity parameters 10 weeks post-TAC as described previously [30, 31]. *Data in bold are statistically significant

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