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Table 7 Prenatal ultrasound findings, genetic results and postnatal outcomes in fetal TOF with a normal cardiac angle group (TOF-CAn) and in fetal TOF with an abnormal cardiac angle group (TOF-CAab)

From: Genetic anomalies in fetuses with tetralogy of Fallot by using high-definition chromosomal microarray analysis

Characteristics

TOF-CAn (N = 73)

TOF-CAab (N = 23)

P value

Maternal age, years

30 (20~42)

30 (19~38)

0.619

Gestational age at diagnosis, weeks

23+ 3 (16+ 2~30+ 3)

22+ 6 (18+ 5~31+ 4)

0.955

TOF type

 TOF-pulmonary valve atresia (%)

13.0 (11/73)

14.3 (3/23)

0.695

 TOF-pulmonary valve stenosis (%)

82.2 (60/73)

87.0 (20/23)

 TOF-an absent pulmonary valve syndrome (%)

2.7 (2/73)

0 (0/23)

Intracardiac anomalies (%)

43.8 (32/73)

39.1 (9/23)

0.691

Extracardiac defects (%)

50.7 (37/73)

52.2 (12/23)

0.901

Genetic anomalies (%)

6.8 (5/73)

39.1 (9/23)

0.001

VOUS (%)

1.4 (1/73)

8.7 (2/23)

0.142

Survival rate (%)

85.7 (18/19)a

88.9 (17/19)a

1.000

  1. aCases that underwent selective reduction or termination of pregnancies were excluded. VOUS, variations of uncertain significance