Table 1 Baseline characteristics
Variable | Healthy subset n = 575 | Remaining cohort n = 1275 | p value |
|---|---|---|---|
Age (years) | 42 [34, 52] | 58 [49, 65] | < 0.001 |
Female gender, n (%) | 328 (57%) | 631 (49%) | 0.003 |
BSA (m2) | 1.82 [1.70, 1.99] | 1.97 [1.82, 2.13] | < 0.001 |
Weight (kg) | 72 [62, 81] | 86 [74, 98] | < 0.001 |
Height (cm) | 171 [165, 179] | 171 [163, 177] | 0.003 |
BMI (kg/m2) | 24 [22, 26] | 29 [26, 33] | < 0.001 |
Systolic blood pressure (mmHg) | 118 [109, 124] | 132 [121, 144] | < 0.001 |
Diastolic blood pressure (mmHg) | 78 [72, 81] | 83 [78, 90] | < 0.001 |
History of CVD, n (%) | 230 (18%) | ||
Antihypertensive medication, n (%) | 606 (48%) | ||
Diabetes mellitus, n (%) | 171 (13%) | ||
Lipid-lowering drugs, n (%) | 298 (23%) | ||
Total serum cholesterol (mmol/l) | 5.02 [4.42, 5.71] | 5.25 [4.57, 5.92] | < 0.001 |
Total serum triglycerides (mmol/l) | 0.97 [0.73, 1.39] | 1.39 [1.03, 2.02] | < 0.001 |
HDL cholesterol (mmol/l) | 1.51 [1.27, 1.76] | 1.34 [1.10, 1.62] | < 0.001 |
LDL cholesterol (mmol/l) | 2.94 [2.37, 3.58] | 3.05 [2.41, 3.65] | 0.091 |
Age group (n) | < 0.001 | ||
under 40 years | 239 | 160 | |
40–60 years | 283 | 556 | |
over 60 years | 53 | 559 |