Skip to main content

Table 2 Summary of findings in hypertrophic cardiomyopathy, dilated cardiomyopathy and aortic stenosis

From: Myocardial tissue characterisation using echocardiographic deformation imaging

Pathological Condition

 

Segmental STE Parameter

 

SRS

SRE

Hypertrophic Cardiomyopathy

 

Myocyte hypertrophy

a

Myocyte disarray

Small intramural coronary arteriole dysplasia

 

Interstitial fibrosis

Dilated Cardiomyopathy

 

Myocyte diameter

↓↓

Interstitial fibrosis

NS

NS

Gene expression

Transforming growth factor ß-1

NS

NS

Collagen type I, Collagen type III

NS

Titin isoform N2B

NA

Titin isoforms N2BA

NA

↓ b

SERCA2a

Phospholamban

NS

NS

Phosphorylated Smad2/3

NS

Protein expression

SERCA2a

Phosphorylated PLB

Phosphorylated Smad2/3

NS

NS

Aortic Stenosis

 

Interstitial fibrosis

Tissue miRNA-21 levels

NS

NS

  1. a) Negative correlation between the absolute value of the deformation and the variable; the higher the value of the variable, the lower the deformation.
  2. b) Positive correlation between the absolute value of the deformation and the variable; the higher the value of the variable, the higher the deformation.
  3. Abbreviations: NA, not assessed or data not provided; NS, not statistically significant; SRS, systolic strain rate; SRE, early diastolic strain rate; STE, speckle tracking echocardiography; SERCA2a, Sarcoplasmic Reticulum Ca2+-ATPase