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Table 2 Summary of findings in hypertrophic cardiomyopathy, dilated cardiomyopathy and aortic stenosis

From: Myocardial tissue characterisation using echocardiographic deformation imaging

Pathological Condition   Segmental STE Parameter
  SRS SRE
Hypertrophic Cardiomyopathy
  Myocyte hypertrophy a
Myocyte disarray
Small intramural coronary arteriole dysplasia
  Interstitial fibrosis
Dilated Cardiomyopathy
  Myocyte diameter ↓↓
Interstitial fibrosis NS NS
Gene expression Transforming growth factor ß-1 NS NS
Collagen type I, Collagen type III NS
Titin isoform N2B NA
Titin isoforms N2BA NA ↓ b
SERCA2a
Phospholamban NS NS
Phosphorylated Smad2/3 NS
Protein expression SERCA2a
Phosphorylated PLB
Phosphorylated Smad2/3 NS NS
Aortic Stenosis
  Interstitial fibrosis
Tissue miRNA-21 levels NS NS
  1. a) Negative correlation between the absolute value of the deformation and the variable; the higher the value of the variable, the lower the deformation.
  2. b) Positive correlation between the absolute value of the deformation and the variable; the higher the value of the variable, the higher the deformation.
  3. Abbreviations: NA, not assessed or data not provided; NS, not statistically significant; SRS, systolic strain rate; SRE, early diastolic strain rate; STE, speckle tracking echocardiography; SERCA2a, Sarcoplasmic Reticulum Ca2+-ATPase