From: Myocardial tissue characterisation using echocardiographic deformation imaging
Pathological Condition | Segmental STE Parameter | ||
---|---|---|---|
SRS | SRE | ||
Hypertrophic Cardiomyopathy | |||
Myocyte hypertrophy | ↓a | ↓ | |
Myocyte disarray | ↓ | ↓ | |
Small intramural coronary arteriole dysplasia | ↓ | ↓ | |
Interstitial fibrosis | ↓ | ↓ | |
Dilated Cardiomyopathy | |||
Myocyte diameter | ↓ | ↓↓ | |
Interstitial fibrosis | NS | NS | |
Gene expression | Transforming growth factor ß-1 | NS | NS |
Collagen type I, Collagen type III | NS | ↓ | |
Titin isoform N2B | NA | ↓ | |
Titin isoforms N2BA | NA | ↓ b | |
SERCA2a | ↓ | ↓ | |
Phospholamban | NS | NS | |
Phosphorylated Smad2/3 | NS | ↓ | |
Protein expression | SERCA2a | ↓ | ↓ |
Phosphorylated PLB | ↓ | ↓ | |
Phosphorylated Smad2/3 | NS | NS | |
Aortic Stenosis | |||
Interstitial fibrosis | ↓ | ↓ | |
Tissue miRNA-21 levels | NS | NS |