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Table 2 Summary of findings in hypertrophic cardiomyopathy, dilated cardiomyopathy and aortic stenosis

From: Myocardial tissue characterisation using echocardiographic deformation imaging

Pathological Condition Segmental STE Parameter
 SRSSRE
Hypertrophic Cardiomyopathy
 Myocyte hypertrophya
Myocyte disarray
Small intramural coronary arteriole dysplasia
 Interstitial fibrosis
Dilated Cardiomyopathy
 Myocyte diameter↓↓
Interstitial fibrosisNSNS
Gene expressionTransforming growth factor ß-1NSNS
Collagen type I, Collagen type IIINS
Titin isoform N2BNA
Titin isoforms N2BANA↓ b
SERCA2a
PhospholambanNSNS
Phosphorylated Smad2/3NS
Protein expressionSERCA2a
Phosphorylated PLB
Phosphorylated Smad2/3NSNS
Aortic Stenosis
 Interstitial fibrosis
Tissue miRNA-21 levelsNSNS
  1. a) Negative correlation between the absolute value of the deformation and the variable; the higher the value of the variable, the lower the deformation.
  2. b) Positive correlation between the absolute value of the deformation and the variable; the higher the value of the variable, the higher the deformation.
  3. Abbreviations: NA, not assessed or data not provided; NS, not statistically significant; SRS, systolic strain rate; SRE, early diastolic strain rate; STE, speckle tracking echocardiography; SERCA2a, Sarcoplasmic Reticulum Ca2+-ATPase