From: Myocardial tissue characterisation using echocardiographic deformation imaging
Pathological Condition | Â | Segmental STE Parameter | |
---|---|---|---|
 | SRS | SRE | |
Hypertrophic Cardiomyopathy | |||
 | Myocyte hypertrophy | ↓a | ↓ |
Myocyte disarray | ↓ | ↓ | |
Small intramural coronary arteriole dysplasia | ↓ | ↓ | |
 | Interstitial fibrosis | ↓ | ↓ |
Dilated Cardiomyopathy | |||
 | Myocyte diameter | ↓ | ↓↓ |
Interstitial fibrosis | NS | NS | |
Gene expression | Transforming growth factor ß-1 | NS | NS |
Collagen type I, Collagen type III | NS | ↓ | |
Titin isoform N2B | NA | ↓ | |
Titin isoforms N2BA | NA | ↓ b | |
SERCA2a | ↓ | ↓ | |
Phospholamban | NS | NS | |
Phosphorylated Smad2/3 | NS | ↓ | |
Protein expression | SERCA2a | ↓ | ↓ |
Phosphorylated PLB | ↓ | ↓ | |
Phosphorylated Smad2/3 | NS | NS | |
Aortic Stenosis | |||
 | Interstitial fibrosis | ↓ | ↓ |
Tissue miRNA-21 levels | NS | NS |