Global longitudinal strain is a hallmark of cardiac damage in mitral regurgitation: the Italian arm of the European Registry of mitral regurgitation (EuMiClip)

Table 3 Differences of echocardiographic parameters between patients with mild vs. moderate to severe MR

Variable	Mild MR n = 392	Moderate to severe MR n = 112	p
LV end-diastolic diameter (mm)	49.3 ± 6.0	53.4 ± 7.8	<0.0001
LV end-systolic diameter (mm)	31.6 ± 6.0	36.2 ± 9.6	<0.0001
LV end-diastolic volume (ml)	86.9 ± 27.9	104.2 ± 38.6	<0.0001
LV end-systolic volume (ml)	33.9 ± 13.5	49.9 ± 28.3	<0.0001
LV EF (%)	61.2 ± 5.8	55.4 ± 10.1	<0.0001
GLS (%)	20.5 ± 3.0	17.5 ± 5.2	<0.0001
LAVi (ml/m²)	28.5 ± 8.5	42.6 ± 17.3	<0.0001
Estimated PASP (mmHg)	29.6 ± 7.5	36.9 ± 11.1	<0.0001

GLS Global longitudinal strain, LAVi LA volume index, LV Left ventricular, PASP Pulmonary arterial systolic pressure

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