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Table 4 Structural predictors of sub-optimal MitraClip response

From: Transcatheter MitraClip repair alters mitral annular geometry – device induced annular remodeling on three-dimensional echocardiography predicts therapeutic response

 Odds Ratio (95% Confidence Interval)pAUCCutoffbSensitivitySpecificity
3D Transesophogeal Echo
 Mitral Annular Area (cm2/m2)1.93 (1.22–3.06)0.0050.72 (0.59–0.84)6.7282%46%
 Annular Circumference (cm/m2)1.96 (1.12–3.41)0.020.65 (0.52–0.79)6.8382%42%
 Antero-Posterior Diameter (cm)7.16 (1.72–29.85)0.0070.72 (0.60–0.85)3.7780%54%
 Anterolateral-Posteromedial Diameter (cm)6.35 (1.58–25.44)0.0090.70 (0.57–0.82)4.0387%38%
 Annular Height (cm)8.27 (0.73–93.28)0.090.63 (0.50–0.77)0.6282%35%
 Tenting Volume (cm3)1.26 (0.93–1.70)0.140.64 (0.50–0.78)2.6982%38%
 Tenting Area (cm2)1.70 (0.85–3.38)0.130.63 (0.49–0.77)1.5180%38%
 Tenting Height (mm)1.17 (0.98–1.40)0.090.64 (0.50–0.79)7.8087%50%
 Anterior Leaflet Angle (°)0.99 (0.96–1.03)0.670.50 (0.35–0.64)24.5582%27%
 Posterior Leaflet Angle (°)1.06 (0.99–1.15)0.110.64 (0.50–0.79)16.0585%46%
 Nonplanar Angle (°)0.97 (0.93–1.01)0.170.40 (0.26–0.54)140.4082%11%
2D Transthoracic Echo
 Mitral Annular Diameter (cm/m2)6.50 (1.27–33.20)0.020.64 (0.51–0.76)1.6781%46%
 LV End-diastolic volume (ml/m2)a1.25 (1.04–1.50)0.010.67 (0.55–0.79)8.4681%39%
 LA Volume (ml/m2)a1.22 (1.03–1.44)0.020.68 (0.56–0.80)5.4183%54%
 LA 2-Chamber area (cm2)1.06 (1.00–1.11)0.040.64 (0.52–0.77)24.6587%33%
 LA 4-Chamber area (cm2)1.09 (1.02–1.16)0.0060.68 (0.56–0.80)27.9581%54%
  1. aper 10 ml increment
  2. bcutoffs chosen for maximum specificity with minimum sensitivity ≥80%
  3. Data in bold are significant