Table 2 Baseline Characteristics by E/A Ratio
E/A ≤ 0.6 | E/A > 0.6–2.3 | E/A > 2.3 | P value | |
|---|---|---|---|---|
No. Patients | 273 | 1010 | 228 | |
Age- yrs. (SD) | 63.9 (9.0) | 60.3 (9.6) | 58.4 (9.2) | < 0.001 |
Female (%) | 50 (18.3) | 163 (16.1) | 20 (8.8) | 0.007 |
Body mass index-m2 (SD) | 27.2 (3.9) | 27.8 (4.8) | 26.7 (4.8) | 0.001 |
Systolic blood pressure-mmHg (SD) | 122.3 (18.2) | 121.7 (17.3) | 115.9 (17.6) | < 0.001 |
Heart rate-bpm (SD) | 71.8 (10.8) | 72.0 (13.5) | 77.4 (16.1) | < 0.001 |
Hemoglobin-g/dL (SD) | 14.0 (1.60) | 13.7 (1.7) | 13.4 (1.9) | 0.001 |
Creatinine-mg/dL (SD) | 1.14 (0.52) | 1.13 (0.56) | 1.18 (0.32) | 0.001 |
Blood urea nitrogen-mg/dL (SD) | 28.7 (18.5) | 27.3 (19.8) | 33.2 (23.5) | 0.001 |
EF-% (SD) | 30.0 (8.2) | 30.1 (8.1) | 26.5 (8.11) | < 0.001 |
LVESVI-cc/m2 (SD) | 80.0 (30.7) | 81.4 (29.8) | 92.3 (31.5) | 0.001 |
Cardiac index-L/min/m2 (SD) | 2.35 (0.70) | 2.37 (0.79) | 2.42 (0.88) | 0.8793 |
E/e’ (SD) | 12.3 (6.2) | 17.0 (8.4) | 26.9 (12.0) | < 0.001 |
Deceleration time-ms (SD) | 243.5 (52.3) | 189.4 (50.3) | 135.8 (27.2) | < 0.001 |
Normal RV function (%) | 224 (88.2) | 776 (83.6) | 96 (43.6) | < 0.001 |
Sphericity index (SD) | 0.67 (0.08) | 0.68 (0.09) | 0.71 (0.08) | < 0.001 |
Beta Blocker (%) | 236 (86.4) | 892 (88.3) | 196 (86.0) | 0.503 |
ACE inhibitor (%) | 219 (80.2) | 826 (81.8) | 188 (82.5) | 0.787 |
Nitrates (%) | 170 (62.3) | 567 (56.1) | 106 (46.3) | 0.002 |
Diuretic (%) | 170 (62.3) | 561 (55.5) | 167 (73.6) | < 0.001 |
Mortality Risk at randomization index | 12.9 (8.5) | 12.1 (8.9) | 14.5 (9.2) | 0.001 |