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Table 3 Subgroup analyses of GLS between DMD and control groups

From: Usefulness of speckle-tracking echocardiography for early detection in children with Duchenne muscular dystrophy: a meta-analysis and trial sequential analysis

 

Number of studies

Test of difference

Test of Heterogeneity

WMD (95% CI)

P value

I2 (%)

P value

Country

 USA/Europe/Egypt

4

5.01 (3.73–6.29)

< 0.001

40.5

0.169

 China/Korea

4

3.28 (1.63–4.93)

< 0.001

62.4

0.047

Quality of study

 Medium quality

5

4.89 (3.78–6.00)

< 0.001

28.3

0.233

 High quality

3

3.04 (1.04–5.05)

0.003

71.5

0.030

Method

 Two-dimensional STE

4

4.90 (3.62–6.19)

< 0.001

40.1

0.171

 Three-dimensional STE

4

3.41 (1.64–5.17)

< 0.001

67.8

0.025

Machine/software

 GE Vivid E9 with EchoPAC

7

4.07 (2.83–5.31)

< 0.001

66.1

0.007

 Philips iE33 with Qlab

1

5.20 (2.51–7.89)

< 0.001

–

–

  1. CI confidence interval, GLS global longitudinal strain, STE speckle tracking echocardiography, WMD weighted mean difference