Table 1 Global parameters and analysis of the variables by age subgroups
Global Md (IQR) | ≤ 30 y n: 14 Md (IQR) | 31–40 y n: 27 Md (IQR) | 41–50 y n: 27 Md (IQR) | 51–60 y n:14 Md (IQR) | ≥ 61 y n: 9 Md (IQR) | p | |
|---|---|---|---|---|---|---|---|
Age (y) | 42 (18) | 23.5 (3.7) | 34 (3.5) | 44 (4) | 53.5 (5.7) | 69 (2) | < 0.0001 |
Female (%) | 54.9 | 64.3 | 33.3 | 63 | 64.3 | 66.7 | NS |
HR (bpm) | 74 (15) | 76.5 (11.7) | 74 (15) | 75 (14.2) | 69.5 (9.7) | 77 (12) | NS |
SBP (mmHg) | 110.5 (16.5) | 95 (18) | 110 (19) | 115 (16) | 115 (17.5) | 126 (8.7) | < 0.0001 |
DBP (mmHg) | 70.5 (10) | 60 (10) | 75 (10) | 76 (10) | 80 (10) | 77.5 (10) | 0.001 |
BSA | 1.83 (0.2) | 1.71 (0.1) | 1.97 (0.3) | 1.83 (0.19) | 1.84 (0.4) | 1.76 (0.1) | 0.03 |
EF (%) | 63 (11.7) | 61 (8) | 63 (13.5) | 66 (11) | 62 (7) | 62.5 (12.2) | NS |
LA Vol Ind (ml/m2) | 22.9 (8) | 20.6 (6.3) | 21.7 (5.4) | 23 (12.4) | 25.2 (5.5) | 22.8 (3.8) | NS |
E (cm/s) | 79 (22.5) | 84.5 (15) | 80 (23.5) | 80 (17.5) | 72.5 (20.5) | 60 (11) | 0.01 |
A (cm/s) | 61 (23.5) | 47.5 (15.2) | 52 (14) | 64 (20) | 80 (17.7) | 78 (20) | < 0.0001 |
E/A | 1.32 (0.7) | 1.79 (0.7) | 1.62 (0.4) | 1.22 (0.5) | 0.98 (0.3) | 0.7 (0.3) | < 0.0001 |
DTE (ms) | 211 (70.5) | 201.5 (68) | 190 (44) | 202 (63) | 228.5 (45) | 292 (152) | 0.003 |
LmaS´ (cm/s) | 10 (3) | 11 (2.7) | 11 (4.5) | 11 (4) | 9 (2.5) | 10 (3) | NS |
LmaE´ (cm/s) | 14 (7) | 17.5 (1.7) | 16 (5) | 14 (4.5) | 11 (3) | 9 (2) | < 0.0001 |
LmaA´ (cm/s) | 9 (4) | 6.5 (3.7) | 8 (2.5) | 9 (3.5) | 9.5 (2.7) | 13 (4) | 0.001 |
LmaE´/LmaA´ | 1.70 (1.12) | 2.70 (2.48) | 2.0 (1.09) | 1.37 (0.65) | 1.10 (0.57) | 0.6 (0.37) | < 0.0001 |
SmaS´ (cm/s) | 8 (2) | 7 (1) | 8 (1) | 8 (2) | 7.5 (1) | 8 (1) | NS |
Sma E´ (cm/s) | 9 (4) | 11 (3.5) | 11 (5) | 9 (3) | 8 (2.7) | 6 (2) | 0.001 |
Sma A´ (cm/s) | 9 (3) | 7 (2) | 8 (3.5) | 9 (3) | 9 (1) | 11 (3) | 0.001 |
Sma E´/Sma A´ | 1.11 (0.81) | 1.73 (0.49) | 1.37 (0.92) | 1 (0.39) | 0.88 (0.31) | 0.57 (0.18) | < 0.0001 |
E/e´ | 6.7 (1.7) | 5.77 (1.3) | 6.17 (1) | 7.01 (1.5) | 7.68 (2.4) | 8.4 (1.7) | 0.0002 |
S’la (cm/s) basal | 11.5 (3) | 10 (2) | 11 (2) | 12 (3) | 11 (3.7) | 12 (3) | NS |
E’la (cm/s) basal | 13 (5) | 15 (5) | 16 (3) | 13 (3) | 10 (2) | 9 (1) | < 0.0001 |
A’la (cm/s) basal | 12 (4) | 10 (3) | 11 (2) | 14 (5) | 12.5 (2.7) | 13 (2) | 0.0006 |
E’la/A’la basal | 1.06 (0.6) | 1.63 (0.5) | 1.42 (0.4) | 0.92 (0.2) | 0.82 (0.2) | 0.64 (0.1) | < 0.0001 |
SRS (1/s) basal | 2.9 (0.9) | 3.6 (1.2) | 3.13 (0.8) | 2.62 (1.1) | 2.54 (0.8) | 2.17 (1.1) | 0.016 |
SRE (1/s) basal | - 2.74 (1.1) | −3.4 (1) | −3.06 (0.6) | −2.26 (1.2) | −2.31 (0.5) | −1.97 (0.2) | < 0.0001 |
SRA (1/s) basal | −2.65 (1.1) | −2.6 (1.2) | −2.48 (1.1) | −2.7 (1.1) | − 2.9 (0.8) | −2.87 (0.7) | NS |
SRE/SRA basal | 1.03 (0.6) | 1.23 (0.1) | 1.19 (0.5) | 0.78 (0.6) | 0.88 (0.2) | 0.69 (0.1) | 0.002 |