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Table 3 Relative risk of all-cause mortality associated with left atrial functional assessment

From: Left atrial functional assessment and mortality in patients with severe aortic stenosis with sinus rhythm

Variable All-cause mortality
HR (95% CI) P value
LAEF
 Unadjusted
   > 53% Reference  
  37–53% 3.57 (2.19–5.83) < 0.001
   < 37% 11.18 (7.01–17.82) < 0.001
 Model 1*
   > 53% Reference  
  37–53% 3.40 (1.57–7.37) 0.002
   < 37% 13.91 (6.20–31.19) < 0.001
 Model 2Ŧ
   > 53% Reference  
  37–53% 3.59 (1.65–7.80) 0.001
   < 37% 11.71 (5.20–26.40) < 0.001
LAPEF
 Unadjusted
   > 28% Reference  
  19–28% 1.64 (1.07–2.51) 0.025
   < 19% 3.72 (2.46–5.61) < 0.001
 Model 1*
   > 28% Reference  
  19–28% 1.58 (0.81–3.08) 0.178
   < 19% 3.07 (1.60–5.90) 0.001
 Model 2Ŧ
   > 28% Reference  
  19–28% 1.43 (0.74–2.76) 0.286
   < 19% 2.29 (1.16–4.54) 0.018
LAAEF
 Unadjusted
   > 34% Reference  
  17–34% 3.27 (1.93–5.54) < 0.001
   < 17% 8.21 (4.98–13.53) < 0.001
 Model 1*
   > 34% Reference  
  17–34% 1.68 (0.77–3.68) 0.196
   < 17% 4.51 (1.99–10.19) < 0.001
 Model 2Ŧ
   > 34% Reference  
  17–34% 1.97 (0.89–4.37) 0.094
   < 17% 4.46 (1.92–10.36) < 0.001
  1. CI denotes confidence interval, HR hazard ratio, LAAEF left atrial active emptying fraction, LAEF left atrial emptying fraction, LAPEF left atrial passive emptying fraction.
  2. *Model 1 was adjusted for very severe aortic stenosis, age at diagnosis, gender, body mass index (BMI), arterial hypertension, chronic kidney disease, coronary artery disease, diabetes, history of malignancy, chronic lung disease, previous symptomatic stroke/transient ischemic attack, Katz index of independence ≤4, dementia, atrial fibrillation appearance during follow-up, LVEF right ventricular enlargement and TAPSE
  3. ŦModel 2 was adjusted for variables used in model 1 and aortic valve replacement during follow-up.