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Table 2 Univariable and multivariable logistic regression analyses of associations between clinical and echocardiographic covariates with stroke

From: Comparison of left atrial and left atrial appendage mechanics in the risk stratification of stroke in patients with atrial fibrillation

Variables Univariate analysis Multivariate analysis
OR (95% CI) P value Model 1 Model 2 Model 3
OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value
Clinical parameters
 Age 1.07 (1.02–1.12) < 0.01 1.06 (1.01–1.13) 0.03 1.07 (1.01–1.14) 0.03 1.08 (1.01–1.40) 0.02
 Female 1.03 (0.46–2.29) 0.94 2.17 (0.79–6.02) 0.14 2.44 (0.85–7.03) 0.09   
 Heart failure 3.19 (1.33–7.62) 0.01 1.85 (0.63–5.45) 0.27 1.56 (0.48–5.24) 0.46   
 CHA2DS2-VASc score 1.41 (1.04–1.19) 0.03 1.04 (0.55–1.97) 0.91 1.14 (0.57–2.29) 0.71 1.07 (0.57–1.63) 0.71
LA parameters
 LAEF 0.97 (0.94–0.99) 0.01 1.00 (0.96–1.04) 0.99     
 iLAVmax 1.02 (1.00–1.04) 0.03 0.99 (0.96–1.02) 0.53    0.99 (0.96–1.03) 0.81
 LA GLS 0.91 (0.86–0.97) < 0.01 0.99 (0.90–1.09) 0.88 0.99 (0.89–1.10) 0.77 0.99 (0.89–1.09) 0.78
 LA MD 1.25 (1.22–1.39) < 0.01 1.20 (1.07–1.36) < 0.01 1.29 (1.11–1.49) < 0.01 1.18 (1.03–1.34) < 0.01
LAA parameters
 LAAEV 0.18 (0.02–1.33) 0.09    16.81 (1.28–220.9) 0.03 4.83 (0.45–52.15) 0.05
 LAAEF 0.98 (0.97–1.00) 0.13    1.01 (0.98–1.05) 0.45   
 LAA dense SEC/thrombus 3.93 (1.64–9.46) < 0.01    4.39 (1.33–14.53) 0.02 3.63 (1.16–11.35) 0.03
 LAA GLS 0.84 (0.75–0.94) < 0.01 0.96 (0.85–1.09) 0.53 0.96 (0.84–1.10) 0.57 0.96 (0.84–1.09) 0.49
 LAA MD 1.21 (1.09–1.32) < 0.01 1.19 (1.07–1.33) < 0.01 1.22 (1.08–1.38) < 0.01 1.21 (1.08–1.36) < 0.01
  1. AF atrial fibrillation, BMI body mass index, CI Confidence intervals, GLS global longitudinal strain, i indexed to body surface area, LA left atrium, LAA left atrial appendage, LAAEF LAA emptying fraction, LAAEV LAA emptying velocity, LAEF LA emptying fraction, MD mechanical dispersion, OR odds ratio, SEC spontaneous echo contrast, Vmax maximal volume