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Table 2 Preoperative and follow-up values for left ventricular and left atrial dimensions, volumes, and function

From: Pre- and postoperative left atrial and ventricular volumetric and deformation analyses in severe aortic regurgitation

  Aortic regurgitation (n = 65) Controls (n = 20) Baseline comparison
Baseline Follow-up p value Baseline Follow-up p value p value
Left ventricular indices
 End-diastolic diameter (mm) 62.6 ± 6 49.3 ± 6 < 0.001 48.5 ± 3 46.2 ± 4 0.005 < 0.001
 End-systolic diameter (mm) 44.0 ± 7 34.4 ± 5 < 0.001 33.1 ± 4 32.5 ± 4 0.80 < 0.001
 Interventricular septum (mm) 11.7 ± 2.0 12.2 ± 1.7 0.004 11.3 ± 2.0 11.4 ± 1.7 0.71 0.48
 Posterior wall thickness (mm) 10.3 ± 1.4 9.5 ± 1.8 0.003 8.9 ± 1.7 9.3 ± 1.6 0.29 < 0.001
 End-diastolic volume (mL) 224 ± 62 132.4 ± 36 < 0.001 109 ± 20 111 ± 23 0.25 < 0.001
 End-diastolic volume index (mL/m2) 113 ± 30 66 ± 17 < 0.001 56 ± 9 57 ± 10 0.40 < 0.001
 End-systolic volume (mL) 103 ± 41 57 ± 18 < 0.001 43 ± 8 45 ± 11 0.25 < 0.001
 End-systolic volume index (mL/m2) 52 ± 20 28 ± 8 < 0.001 22 ± 4 23 ± 5 0.41 < 0.001
 Stroke volume (mL) 121 ± 31 76 ± 22 < 0.001 65 ± 14 66 ± 15 0.41 < 0.001
 Ejection fraction (%) 55 ± 7.3 57 ± 7.1 0.027a 60 ± 4 60 ± 7 0.79 < 0.001
 Global longitudinal strain (|%|) 19.0 ± 3.0 19.4 ± 2.5 0.34 19.9 ± 2 19.6 ± 2 0.54 0.24
 Left ventricular mass index (g/m2) 81 ± 19 62 ± 16 < 0.001 48 ± 11 48 ± 11 0.87 < 0.001
Diastolic function indices
 Mitral E velocity (m/s) 0.76 ± 0.2 0.73 ± 0.2 0.17 0.70 ± 0.2 0.76 ± 0.2 0.14 0.23
 Mitral A velocity (m/s) 0.58 ± 0.2 0.59 ± 0.2 0.84 0.63 ± 0.2 0.66 ± 0.2 0.38 0.30
 Mitral E/A ratio 1.5 ± 0.7 1.3 ± 0.5 0.063 1.3 ± 0.8 1.2 ± 0.6 0.93 0.17
 Mitral E-wave Deceleration time (ms) 205 ± 57 238 ± 52 0.001 212 ± 44 232 ± 52 0.11 0.66
 Septal e′ (m/s) 0.074 ± 0.02 0.075 ± 0.02 0.85 0.066 ± 0.02 0.070 ± 0.02 0.46 0.11
 Lateral e′ (m/s) 0.097 ± 0.03 0.12 ± 0.03 0.005 0.087 ± 0.02 0.10 ± 0.01 0.071 0.13
 Mitral average E/e′ ratio 9.3 ± 3 8.0 ± 3 0.012 10.2 ± 3 9.1 ± 2 0.31 0.30
 Tricuspid regurgitation velocity (m/s) 2.5 ± 0.3 2.3 ± 0.4 0.080 2.3 ± 0.2 2.3 ± 0.2 0.33 0.047a
Diastolic dysfunction grade
 0 or 1 39 (60%) 55 (85%) 0.003 20 (100%) 18 (90%) 0.30 0.002
 2 6 (9%) 2 (3%)   0 1 (5%)   
 3 15 (23%) 5 (8%)   0 0   
 Indeterminate 5 (8%) 3 (4%)   0 1 (5%)   
Left atrial indices
 Left atrial volume index (ml/m2) 38.6 ± 12 32.2 ± 11 < 0.001 26.8 ± 8 27.4 ± 8 0.70 < 0.001
 LASr (%) 26.3 ± 6.7 29.0 ± 6.2 0.012 25.7 ± 6.0 25.8 ± 4.7 0.92 0.86
 LAScd (%) 15.6 ± 6.1 14.0 ± 4.5 0.037a 12.1 ± 3.5 11.9 ± 3.7 0.28 0.081
 LASct (%) 11.0 ± 4.7 15.3 ± 5.5 < 0.001 12.8 ± 5.6 13.8 ± 4.2 0.43 0.049a
  1. aNon-significant after Bonferroni correction at α = 0.017; e′, tissue doppler-derived mitral annular early diastolic velocity, LAScd Left atrial strain conduit phase, LASct Left atrial strain contraction phase, LASr Left atrial strain reservoir phase