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Table 2 Incremental benefits of categorical echocardiographic parameters over the base model

From: Cardiac amyloidosis screening using a relative apical sparing pattern in patients with left ventricular hypertrophy

  AUC (95% CI) p value
(base model vs base model plus each echo parameter)
Base model: Age (≥65 [men], ≥70 [women])
+ Low voltage+ PWT ≥14.0 mm
0.82 (0.76–0.88)  
+ LV ejection fraction ≤55% 0.83 (0.76–0.90) 0.67
+ E/e’ > 12 0.84 (0.78–0.90) 0.34
+ LA volume index ≥47 (mL/m2) 0.84 (0.77–0.91) 0.13
+ Pericardial effusion 0.83 (0.76–0.89) 0.37
+ Granular sparkling 0.82 (0.75–0.88) 0.82
+ Interatrial septal thickness ≥ 4 mm 0.83 (0.77–0.89) 0.54
+ Right ventricular wall thickness ≥ 6 mm 0.81 (0.75–0.88) 0.58
+ Anterior mitral valve leaflet thickness ≥ 5 mm 0.81 (0.74–0.87) 0.49
+ GLS ≥ -16% 0.82 (0.75–0.88) 0.98
+ GLS ≥ -17% 0.82 (0.75–0.88) 0.90
+ Ejection fraction strain ratio > 3.9% 0.83 (0.77–0.90) 0.13
+ LA reservoir strain < 19% 0.84 (0.78–0.90) 0.16
+ qRASP > 1.00 0.87 (0.80–0.93) < 0.01
+ qRASP > 0.90 0.87 (0.80–0.93) < 0.01
+ qRASP > 0.87 0.86 (0.80–0.93) 0.01
+ sRASP 0.87 (0.81–0.93) 0.03
  1. AUC indicates area under the curve; CI, confidence interval; GLS, global longitudinal strain; LA, left atrial; LV, left ventricular; PWT, posterior wall thickness; qRASP, quantitatively assessed relative apical sparing pattern of longitudinal strain; sRASP, semi-quantitatively assessed relative apical sparing pattern of longitudinal strain