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Table 2 Incremental benefits of categorical echocardiographic parameters over the base model

From: Cardiac amyloidosis screening using a relative apical sparing pattern in patients with left ventricular hypertrophy

 

AUC (95% CI)

p value

(base model vs base model plus each echo parameter)

Base model: Age (≥65 [men], ≥70 [women])

+ Low voltage+ PWT ≥14.0 mm

0.82 (0.76–0.88)

 

+ LV ejection fraction ≤55%

0.83 (0.76–0.90)

0.67

+ E/e’ > 12

0.84 (0.78–0.90)

0.34

+ LA volume index ≥47 (mL/m2)

0.84 (0.77–0.91)

0.13

+ Pericardial effusion

0.83 (0.76–0.89)

0.37

+ Granular sparkling

0.82 (0.75–0.88)

0.82

+ Interatrial septal thickness ≥ 4 mm

0.83 (0.77–0.89)

0.54

+ Right ventricular wall thickness ≥ 6 mm

0.81 (0.75–0.88)

0.58

+ Anterior mitral valve leaflet thickness ≥ 5 mm

0.81 (0.74–0.87)

0.49

+ GLS ≥ -16%

0.82 (0.75–0.88)

0.98

+ GLS ≥ -17%

0.82 (0.75–0.88)

0.90

+ Ejection fraction strain ratio > 3.9%

0.83 (0.77–0.90)

0.13

+ LA reservoir strain < 19%

0.84 (0.78–0.90)

0.16

+ qRASP > 1.00

0.87 (0.80–0.93)

< 0.01

+ qRASP > 0.90

0.87 (0.80–0.93)

< 0.01

+ qRASP > 0.87

0.86 (0.80–0.93)

0.01

+ sRASP

0.87 (0.81–0.93)

0.03

  1. AUC indicates area under the curve; CI, confidence interval; GLS, global longitudinal strain; LA, left atrial; LV, left ventricular; PWT, posterior wall thickness; qRASP, quantitatively assessed relative apical sparing pattern of longitudinal strain; sRASP, semi-quantitatively assessed relative apical sparing pattern of longitudinal strain