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Table 3 ROC curve analysis of echocardiographic parameters to predict NT-proBNP ≥500 ng/L in patients with severe aortic stenosis

From: Echocardiographic assessment of diastolic dysfunction in elderly patients with severe aortic stenosis before and after aortic valve replacement

N = 210 NT-proBNP ≥500
N = 123 NT-proBNP < 500
AUC CI Lower bound CI Upper bound P-value
e’septal (cm/s) 0.68 0.62 0.73 < 0.0001
e’lateral (cm/s) 0.62 0.55 0.68 0.001
e’avrg (cm/s) 0.62 0.56 0.68 0.002
E/e’sept () 0.70 0.65 0.76 < 0.0001
E/e’lat () 0.63 0.56 0.69 < 0.0001
E/e’avrg () 0.67 0.61 0.73 < 0.0001
PV SFF 0.68 0.63 0.74 < 0.0001
LA volume (ml) 0.73 0.67 0.79 < 0.0001
MV peak E (cm/s) 0.64 0.58 0.70 0.050
MV peak A (cm/s) 0.50 0.44 0.57 0.939
MV E/A () 0.57 0.51 0.64 0.037
MV dec time (ms) 0.66 0.61 0.72 < 0.0001
IVRT (ms) 0.56 0.50 0.62 0.057
PAP (mmHg) 0.68 0.63 0.74 < 0.0001
Score 2016 0.72 0.67 0.78 < 0.0001
Score 1 e’sept 0.76 0.71 0.82 < 0.0001
Score 2 E/é avrg 0.70 0.65 0.77 < 0.0001
  1. A Late (atrial) diastolic transmitral flow velocity, AUC Area Under the Curve, CI Confidence interval, E Early diastolic transmitral flow velocity, e′ Early diastolic mitral annuler velocity, IVRT Isovolumic relaxation time, LA Left atrium, MV dec time Mirtal valve deceleration time, MV peak E Mitral valve early diastolic filling velocity, MV peak A Mitral valve late diastolic atrial filling velocity, NT-proBNP N-terminal prohormone of brain natriuretic peptide, PAP Pulmonary artery pressure, ROC Receiver operating characteristic