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Table 5 Cut-off values, sensitivity and specificity for detection of elevated NT-proBNP

From: Echocardiographic assessment of diastolic dysfunction in elderly patients with severe aortic stenosis before and after aortic valve replacement

  N pos N neg A B C
Cut-off A Sensitivity (%) Specificity (%) Cut-off B Sensitivity (%) Specificity (%) Cut off C Sensitivity (%) Specificity (%)
e’septal (cm/s) 227 129 6.0 83 35 5.5 75 53 5.0 64 60
e’avrg (cm/s) 227 129 7.0 72 39 6.0 65 56 5.5 45 72
E/e’sept () 227 129 16 72 50 18 64 65 20 55 76
E/e’avrg () 227 129 14 67 57 15 58 66 16 54 70
PV SFF 220 128 60 80 41 55 67 63 50 55 77
LA volume (ml) 227 130 70 85 43 80 73 60 90 61 75
PAP (mmHg) 220 128 30 84 31 35 61 74 40 41 90
Peak E (cm/s) 228 130 80 68 45 90 59 63 100 52 81
E DT (ms) 228 130 280 68 52 250 59 68 220 44 81
Score of the parameters above    <Cut-off A: -1    Cut-off A to C = 0     >Cut-off C: +1   
Sum Score of e’sept*peakE* DT *PAP 219 125 −1.5 82 51 −0.5 62 73 0.5 45 92
Sum Score of: E/ e’sept *peakE *DT *PAP 196 123 −1.5 66 63 −0.5 55 72 0.5 40 86
Score 2016 214 124 1.5 93 23 2.5 68 68 3.5 27 96
  1. Score: sum of score for the three independent parameters <cutoff A = -1; between cut-off A and C: 0; ≥cut-off C = 1
  2. DT Deceleration time, E Early diastolic transmitral flow velocity, e′ Early diastolic mitral annuler velocity, IVRT Isovolumic relaxation time, LA Left atrium, NT-proBNP N-terminal prohormone of brain natriuretic peptide, PAP Pulmonary artery pressure, PV SFF Pulmonary veins systolic filling fraction