Table 3 Correlations of galectin-3 (ln) and ST2 (ln) with the echocardiographic parameters of the LV and LA size and mechanics in SSc patients
Parameter | Value | Correlations with ln galectin-3 | Correlations with ln galectin-3, corrected for age | Correlations with ln ST2 | Correlations with ln ST2, corrected for age | |||||
|---|---|---|---|---|---|---|---|---|---|---|
r | p | r | p | r | p | r | p | |||
LV ejection fraction (%) | 60.6 ± 4.6 | −0.273 | 0.089 | −0.267 | 0.100 | 0.082 | 0.614 | 0.082 | 0.618 | |
LV GLS (%) | −17.5 ± 2.3 | 0.454 | 0.005 | 0.460 | 0.005 | 0.003 | 0.988 | − 0.007 | 0.969 | |
LV mass index (g/m2) | 93.5 ± 19.7 | 0.009 | 0.958 | −0.039 | 0.814 | −0.147 | 0.367 | −0.184 | 0.262 | |
Grade of mitral regurgitation | Mild n (%) | 37 (92.5%) | 0.321 | 0.046 | 0.323 | 0.048 | −0.078 | 0.637 | −0.080 | 0.632 |
Moderate n (%) | 3 (7.5%) | |||||||||
Severe n (%) | 0 (0%) | |||||||||
Mitral E (cm/s) | 73.9 ± 15.7 | 0.006 | 0.970 | 0.028 | 0.867 | −0.022 | 0.892 | −0.027 | 0.869 | |
Mitral A (cm/s) | 72.8 ± 16.9 | 0.320 | 0.044 | 0.334 | 0.038 | 0.132 | 0.417 | 0.156 | 0.342 | |
Septal S (cm/s) | 7.3 ± 1.2 | −0.224 | 0.166 | − 0.220 | 0.178 | 0.080 | 0.624 | 0.084 | 0.612 | |
Septal e’ (cm/s) | 7.4 ± 2.0 | −0.306 | 0.055 | −0.369 | 0.021 | −0.088 | 0.591 | −0.131 | 0.426 | |
Septal a’ (cm/s) | 8.7 ± 1.6 | −0.012 | 0.939 | −0.018 | 0.912 | 0.181 | 0.263 | 0.183 | 0.265 | |
Septal E/e’ | 10.5 ± 2.8 | 0.375 | 0.017 | 0.380 | 0.017 | 0.002 | 0.989 | 0.006 | 0.970 | |
Lateral S (cm/s) | 9.2 ± 1.8 | −0.008 | 0.963 | 0.004 | 0.980 | 0.212 | 0.189 | 0.214 | 0.190 | |
Lateral e’ (cm/s) | 9.2 ± 2.8 | −0.132 | 0.418 | −0.119 | 0.471 | 0.019 | 0.906 | 0.016 | 0.922 | |
Lateral a’ (cm/s) | 10.6 ± 2.5 | 0.031 | 0.848 | 0.012 | 0.944 | 0.276 | 0.085 | 0.298 | 0.066 | |
Lateral E/e’ | 8.7 ± 3.0 | 0.109 | 0.502 | 0.106 | 0.522 | −0.063 | 0.699 | − 0.063 | 0.705 | |
Averaged S (cm/s) | 8.3 ± 1.3 | −0.107 | 0.510 | −0.093 | 0.573 | 0.182 | 0.261 | 0.189 | 0.248 | |
Averaged e’ (cm/s) | 8.3 ± 2.2 | −0.224 | 0.165 | −0.248 | 0.128 | −0.027 | 0.867 | −0.045 | 0.784 | |
Averaged a’ (cm/s) | 9.7 ± 1.7 | 0.017 | 0.918 | −0.001 | 0.998 | 0.282 | 0.078 | 0.298 | 0.066 | |
Averaged E/e’ | 9.3 ± 2.3 | 0.252 | 0.117 | 0.246 | 0.132 | −0.032 | 0.846 | −0.030 | 0.856 | |
Grade of LV diastolic function | Normal n (%) | 11 (27.5%) | 0.325 | 0.040 | 0.394 | 0.013 | −0.073 | 0.655 | −0.091 | 0.582 |
Impaired relaxation (Grade I) n (%) | 17 (42.5%) | |||||||||
Pseudonormal (Grade II) n (%) | 12 (30%) | |||||||||
LA Vmax index (ml/m2) | 22.8 ± 7.4 | 0.016 | 0.925 | 0.001 | 0.994 | −0.294 | 0.081 | −0.392 | 0.076 | |
LA Vmin index (ml/m2) | 10.3 ± 5.0 | 0.056 | 0.747 | 0.044 | 0.803 | −0.305 | 0.071 | −0.410 | 0.078 | |
LA Vp index (ml/m2) | 14.2 ± 6.1 | 0.095 | 0.580 | 0.088 | 0.617 | −0.237 | 0.164 | −0.360 | 0.111 | |
LA reservoir strain (%) | 43.0 ± 8.7 | −0.148 | 0.383 | −0.154 | 0.370 | −0.045 | 0.790 | −0.005 | 0.978 | |
LA conduit strain (%) | 23.5 ± 6.9 | −0.117 | 0.491 | −0.137 | 0.426 | −0.066 | 0.700 | 0.005 | 0.979 | |
LA contractile strain (%) | 19.5 ± 4.8 | −0.102 | 0.549 | −0.106 | 0.538 | 0.012 | 0.945 | −0.014 | 0.936 | |