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Table 4 Diagnostic performance of cut-off values to detect patients with decompensation and overt LVF

From: A novel echocardiographic right ventricular dysfunction score can identify hemodynamic severity profiles in left ventricular dysfunction

  Cut-off Sensitivity (95% CI) Specificity (95% CI) PLR (95% CI) NLR (95% CI)
Decompensated LVD (PCWP ≥ 15 mmHg)
 NT-proBNP  ≥ 2000 ng/L 75 (60–83) 73 (58–84) 2.7 (1.7–4.8) 0.37 (0.23–0.59)
 LVEF  < 27% 69 (56–79) 69 (54–81) 2.2 (1.4–3.6) 0.45 (0.29–0.69)
 Standard echocardiography   91(80–97) 68 (49–82) 2.8 (1.7–4.9) 0.13 (0.05–0.33)
 RVD score  ≥ 1 96 (88–99) 41 (26–58) 1.6 (1.2–2.2) 0.09 (0.02–0.37)
 RVD score  ≥ 2 76 (64–86) 85 (70–94) 5.2 (2.3–11.8) 0.28 (0.17–0.46)
Overt LVF (PCWP ≥ 15 mmHg and SvO2 < 60%)
 NT-proBNP  ≥ 3100 ng/L 82 (66–91) 77 (65–85) 3.5 (2.2–5.6) 0.24 (0.11–0.50)
 LVEF  < 25% 61 (44–75) 69 (57–78) 1.9 (1.2–3.0) 0.57 (0.37–0.90)
 Standard echocardiography   73 (54–86) 74 (60–85) 2.9 (1.7–4.9) 0.36 (0.19–0.70)
 RVD score  ≥ 2 97 (84–99) 72 (59–82) 3.5 (2.3–5.3) 0.04 (0.006–0.30)
 RVD score  ≥ 4 47 (31–64) 93 (83–97) 6.7 (2.4–18.4) 0.57 (0.41–0.80)
  1. CI Confidence interval, LVD Left ventricular dysfunction, LVF Left ventricular failure, NLR Negative likelihood ratio, PCWP Pulmonary capillary wedge pressure, PLR Positive likelihood ratio, RVF Right ventricular failure, RVD Right ventricular dysfunction, SvO2 mixed venous saturation