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Table 1 Characteristics of the 14 eligible studies for meta-analysis

From: Global longitudinal strain for detection of cardiac iron overload in patients with thalassemia: a meta-analysis of observational studies with individual-level participant data

Studies Year of publication Country Age Male (%) No. of patients Echocardiographic data
T2* ≥ 20 T2* < 20 GLS LVEF
T2* ≥ 20 T2* < 20 T2* ≥ 20 T2* < 20
Pizzino et al. [21] 2017 Italy 37.4 ± 10 53% 22 6 21.3 ± 2.7 18.3 ± 2 60.2 ± 4.8 58 ± 2.4
Parsaee et al. [15] 2018 Iran 30.79 ± 9.37 45% 81 41 -19 (-18 to -20) -17 (-19 to -16) 63 (59–68) 58 (53–63)
Abtahi et al. [22] 2019 Iran 23.7 ± 5 56% 28 22 21.55 ± 2.68 17.64 ± 2.56 58.5 ± 5 59.32 ± 4.9
Ari et al. [16] 2017 Turkey 13.3 ± 16.1 50% 20 10 -23.10 ± 2.20 -19.70 ± 3.10 68.3 ± 3.5
Rezaeian et al. [17] 2020 Iran 24.66 ± 6.23 57.1% 25 66 -13.81 ± 3.25 -12.9 ± 4.18 52.0 ± 12.4
Hanneman et al. [23] 2016 Canada 34.6 ± 9.5 53% 11 19 -18.8 ± 3.5 -19.4 ± 1.8 58.5 ± 5.5 60.4 ± 4.4
Parsaee et al. [24] 2019 Iran 31.96 ± 7.5 44.4% 25 20 -22.36 ± 2.34 -21.73 ± 1.71 -
Garceau et al. [25] 2011 Canada 34.4 ± 11 46.6% 23 22 -20 ± 2 -16 ± 3 64 ± 5 59 ± 7
Nadar et al. [26] 2020 Oman 26.3 ± 6.1 42.8% 61 23 -19.2 ± 2.8 -18.6 ± 2.4 59.5 ± 6.7 60.4 ± 5.2
El-Shanshory et al. [4] 2020 Egypt 10.9 ± 3.7 66.6% 68 32 -21.23 ± 2.68 -21.375 ± 2.06 54.88 ± 12.47 49.88 ± 14.04
Djer et al. [28] 2020 Indonesia 13–41 50% 16 14 - 65.6 (60.6–75.5) 64.8 (60.5–75)
Barzin et al. [29] 2012 Iran 23.5 (15–37) 48.4% 16 14 - 60.3 ± 3.99 51.1 ± 4.39
Poorzand et al. [30] 2019 Iran 23.51 ± 6.2 52.35% 30 14 -20.28 ± 1.67 -18.23 ± 3.41 58.6 ± 2.87 56.05 ± 8.8
Odoardo et al. [31] 2017 Italy 36.6 ± 7 38.2% 34 21 -19.2 ± 3 -18.8 ± 2.6 61 ± 5.3 60.6 ± 6.2